Results 231 to 240 of about 776,529 (356)

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Evaluation of the prophylactic action of veterinary dental gel containing Aloe vera and green tea on calculus formation in dogs submitted to periodontal treatment

, 2022
Nina Gabriela Silva Gualberto, Lorena Priscila Oliveira Andrade, Camila Fernanda Oliveira Andrade, Paulo Eduardo Ambrósio, Amauri Arias Wenceslau, Elisângela Barboza da Silva, Mário Sérgio Lima de Lavor, Renata Santiago Alberto Carlos   +7 more
openalex   +2 more sources

Plant microremains in dental calculus and diet breadth [PDF]

, 2014
Chelsea Leonard, Layne Vashro, James O'Connell, Amanda G. Henry   +3 more
openalex  

Relationship between past myocardial infarction, periodontal disease and Porphyromonas gingivalis serum antibodies : a case-control study [PDF]

, 2018
Czarnecka, Danuta, Jankowski, Piotr, Micek, Agnieszka, Pająk, Andrzej, Polak, Maciej, Potempa, Jan, Szafraniec, Krystyna, Wolfshaut-Wolak, Renata, Łysek, Radosław   +8 more
core   +1 more source

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

Tooth wear and dental calculus in a group of orca (<i>Orcinus orca</i>) stranded on the New Zealand southern coast. [PDF]

J R Soc N Z
Loch C, Visser IN, Stratford K, White S, Wakefield J, Bull S, Matenga L, Johnstone M, Oliphant-Stewart R.   +8 more
europepmc   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

Advanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
wiley   +1 more source

Isotope analysis of human dental calculus δ¹³ CO₃ ^2- : Investigating a potential new proxy for sugar consumption. [PDF]

Rapid Commun Mass Spectrom, 2022
Chidimuro B, Mundorff A, Speller C, Radini A, Boudreault N, Lucas M, Holst M, Lamb A, Collins M, Alexander M.   +9 more
europepmc   +1 more source

Effectiveness of Decontamination protocols when Analyzing Ancient DNA Preserved in Dental Calculus

, 2020
Andrew G. Farrer, Sterling Wright, Emily Skelly, Raphael Eisenhofer, Keith Dobney, Laura S. Weyrich   +5 more
openalex   +1 more source