Results 281 to 290 of about 788,740 (309)

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, EarlyView.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source

Multiscale 3D Whole Joint Cellular and Molecular Mapping Reveals Disease‐Specific Neurovascular Plasticity Underlying the Structure‐Pain Relationship

Advanced Science, EarlyView.
This study presents MUSIC, a novel immunostaining and clearing method coupled with large‐field light sheet microscopy, enabling 3D high‐resolution cellular and molecular mapping of intact musculoskeletal joints across species and joint types. Using joint degenerative and injury models, disease‐specific neurovascular alterations are uncovered, revealing
Peng Chen, Jiaxin Chai, Abirami Soundararajan, R. Glenn Hepfer, Benjamin Kheyfets, Jiaxin Hu, Ishraq Alshanqiti, Swarnalakshmi Raman, Ikue Tosa, Jun Tae Huh, Matthew Yee, Brooke J. Damon, Shangping Wang, Yu Shin Kim, Man‐Kyo Chung, Mildred C. Embree, Janice S. Lee, Tong Ye, Hai Yao   +18 more
wiley   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

IN VITRO EVALUATION OF A DIFFERENTIAL REFLECTOMETRY DENTAL CALCULUS DETECTION INSTRUMENT

, 2017
Jennifer Lopes
openalex   +1 more source

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Association between Dental Calculus and Hypertension Phenotypes in Highly Fit Adults: CHIEF Oral Health Study.

American Journal of Hypertension, 2022
BACKGROUND Poor oral health evaluated by presence of dental calculus has been associated with hypertension (HTN) among middle- and old-aged adults.
Kun-Zhe Tsai, Ren-Yeong Huang, Wan-Chien Cheng, Chih-lu Han, Wei-Chun Huang, X. Sui, C. Lavie, Gen-Min Lin   +7 more
semanticscholar   +1 more source

Cytotoxic effects of dental calculus particles and freeze-dried Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum on HSC-2 oral epithelial cells and THP-1 macrophages.

The Journal of Periodontology, 2021
BACKGROUND Periodontitis is an inflammatory disease initiated by dental deposits. Microorganisms in the dental biofilm induce cell death in epithelial cells, contributing to the breakdown of epithelial barrier function. Recently, dental calculus has also
S. Ziauddin, Mohammad Ibtehaz Alam, Megumi Mae, Masayuki Oohira, K. Higuchi, Y. Yamashita, Y. Ozaki, A. Yoshimura   +7 more
semanticscholar   +1 more source

Dental calculus: the calcified biofilm and its role in disease development

Periodontology 2000, 2018
A. Akcalı, N. Lang
exaly   +2 more sources

Microfossil analysis of dental calculus and isotopic measurements reveal the complexity of human-plant dietary relationships in Late Bronze Age Yunnan

Archaeological and Anthropological Sciences, 2022
Tingting Wang, D. Wei, Zhilong Jiang, Xiumin Xia, Yan Wu, Z. Han, Yating Qu, Yaowu Hu, B. Fuller   +8 more
semanticscholar   +1 more source

Exploitation and utilization of tropical rainforests indicated in dental calculus of ancient Oceanic Lapita culture colonists

Nature Human Behaviour, 2020
M. Tromp, E. Matisoo-Smith, R. Kinaston, S. Bedford, M. Spriggs, H. Buckley   +5 more
semanticscholar   +1 more source