Results 181 to 190 of about 17,868 (251)

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

open access: yesBrain Pathology, EarlyView.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen   +12 more
wiley   +1 more source

Is there a role for hypnosis in palliative care? [PDF]

open access: yesPalliat Care Soc Pract
Vayne-Bossert P, Hardy J.
europepmc   +1 more source

Peri‐Implant Crevicular Fluid Analysis by Mid‐Infrared Spectroscopy in Peri‐Implantitis—A Pilot Study

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objectives This study aimed to assess biochemical differences in peri‐implant crevicular fluid (PICF) using ATR‐FTIR spectroscopy and multivariate analysis, through a between‐participant comparison of healthy and peri‐implantitis (PI) sites, and a within‐participant comparison of PI‐PICF and GCF from contralateral periodontal healthy teeth ...
Francisco Maligno   +2 more
wiley   +1 more source

FAM20A Deficiency Drives Transcriptomic Dysregulation and Functional Impairment in Gingival Fibroblasts

open access: yesCell Proliferation, EarlyView.
FAM20A variants cause AI1G, marked by enamel defects, gingival overgrowth and ectopic calcifications. RNA sequencing of patient‐derived gingival fibroblasts showed dysregulated genes in adhesion, proliferation and signalling pathways. Functional assays revealed increased cell proliferation, impaired ECM interactions and osteogenesis, suggesting FAM20A ...
Kanokwan Sriwattanapong   +9 more
wiley   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

open access: yesCell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao   +11 more
wiley   +1 more source

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