Results 51 to 60 of about 2,252,268 (295)

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Use of adhesive systems in dentistry: past and present [PDF]

Саратовский научно-медицинский журнал, 2018
In recent decades, in the sphere of minimally invasive approach to preparing hard dental tissues, adhesive dentistry has made significant progress, revolutionizing many aspects of restorative dentistry. The attitude towards cavity preparation has changed
Aslanyan M.A., Eremin O.V., Trufanova Yu.Yu., Aslanyan Mel.A., Eremin А.О., Bykova О.A., Zavyalov A.I.   +6 more
doaj  

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Effect of prior haptic virtual reality simulation on preclinical endodontic access cavity preparation

Frontiers in Oral Health
IntroductionHaptic virtual reality simulation (HVRS) has emerged as a promising tool in dental education, supporting technical skill acquisition through interactive and feedback-rich environments.
Germán Sánchez-Herrera, Germán Sánchez-Herrera, Ola Deeb, Fernando José Alfaro-Ochoa, Martín Pérez-Leal, Cristina Palma-Carrió, Nicla Flacco   +6 more
doaj   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Evaluation of bond strength of silorane and methacrylate based restorative systems to dentin using different cavity models

Journal of Applied Oral Science, 2013
OBJECTIVE: The aim of this in vitro study was to evaluate the microtensile bond strength (µTBS) to dentin of two different restorative systems: silorane-based (P90), and methacrylate-based (P60), using two cavity models.
Stephano Zerlottini Isaac, Ana Claudia Pietrobom Bergamin, Cecilia Pedroso Turssi, Flavia Lucisano Botelho do Amaral, Roberta Tarkany Basting, Fabiana Mantovani Gomes Franca   +5 more
doaj   +1 more source

Child and teenager oral health and dental visiting: results from the National Dental Telephone Interview Survey 2010 [PDF]

, 2013
This publication reports on oral health, dental visiting and dental treatment needs of Australian children as reported in the National Dental Telephone Interview Survey (NDTIS) 2010.
Luzzi, L., Harford, J.E., L. Luzzi, J.E. Harford   +3 more
core  

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Effect of Different Placement Techniques on Microleakage of Class V Composite Restorations

Frontiers in Dentistry, 2009
Objective: Various techniques of composite placement have been used to decrease microleakage around the composite restorations. Due to controversial results, the present study was conducted to investigate the effect of different placement techniques ...
M. Moezyzadeh, M. Kazemipoor   +1 more
doaj