Results 221 to 230 of about 1,678,629 (281)

Reln mRNA Delivery Drives Neurogenic Bone Regeneration by Orchestrating Schwann Cell‐Mediated Exosomal Trafficking

Advanced Science, EarlyView.
MSNs serve as a robust vehicle for CRISPRa‐mediated Reln induction, driving bone repair through the establishment of a neurogenic‐supportive microenvironment. ABSTRACT Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, while the mechanisms and new strategies underlying neurogenic bone regeneration ...
Shuai Lin, Qianwen Li, Duo Liu, Mingzhao Li, Han Zhang, Liujing Chen, Yan Yu, Jiuhui Jiang, Chun Xu, Ruili Yang   +9 more
wiley   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Dynamic Supercooled Crystal–Gels for Ultrafast, Reversible Mechanical Adaptative Materials

Advanced Science, EarlyView.
A dynamic supercooled crystal–gel mimics starfish tissue by storing non‐equilibrium energy in a metastable liquid. A gentle touch triggers templated crystallization, producing a 2596‐fold stiffness increase with negligible volume change. The lattice disintegrates reversibly under humidity or warmth.
Yuesong Lv, Hao Feng, Zhangqin Yang, Jianping Yin, Hanfei Li, Bo Zhou, Yuyang Meng, Yuntong Su, Xinxing Zhang, Xibo Pei   +9 more
wiley   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Clinical Implementation and Perioperative Outcomes of Robot‐Assisted Pelvic Exenteration for Primary Rectal Cancer: A Multicenter Japanese Experience

Annals of Gastroenterological Surgery, EarlyView.
Robot‐assisted pelvic exenteration (RPE) was performed with acceptable perioperative outcomes in selected patients with primary rectal cancer. It may serve as a complementary approach at institutions with sufficient experience in PE, whereas open surgery remains essential for extensive or technically demanding disease.
Shoma Yamamoto, Hiroyasu Kagawa, Yusuke Yatabe, Yusuke Kinugasa   +3 more
wiley   +1 more source

Impact of Laparoscopic Liver Resection on Long‐Term Outcomes and Non‐Liver‐Related Mortality in Elderly Patients With Primary Hepatocellular Carcinoma: A Multicenter Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter, propensity score–matched study of elderly patients with primary hepatocellular carcinoma, we compared long‐term cause‐specific mortality between laparoscopic (LLR) and open liver resection (OLR) using a competing‐risks framework. Among patients aged ≥ 80 years, LLR was associated with a lower 5‐year cumulative incidence of death ...
Yukio Tokumitsu, Hidenori Takahashi, Yuki Nakagami, Toru Hisaka, Hiromitsu Hayashi, Tomoharu Yoshizumi, Norifumi Harimoto, Takao Ide, Yoichi Yamasaki, Atsushi Miyoshi, Yuichi Endo, Tamotsu Kuroki, Atsushi Nanashima, Masahiko Sakoda, Tohru Utsunomiya, Kohji Okamoto, Masatoshi Kajiwara, Mitsuhisa Takatsuki, Toru Beppu, Susumu Eguchi   +19 more
wiley   +1 more source

Current Standards of Monitoring Models in Healthcare Settings

Advanced Intelligent Discovery, EarlyView.
AI/ML‐enabled medical devices are entering clinical practice faster than monitoring standards mature. This review highlights gaps in postmarket surveillance, limited use of predetermined change‐control plans, and the need for ongoing performance tracking, drift detection, explainability, and workflow‐aware governance to support safer, more reliable ...
Alan Kay, Daljit Takher, Wenting Liu, Emily Wittrup, Gilbert S. Omenn, Kayvan Najarian   +5 more
wiley   +1 more source

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Siloranes in dental composites

Dental Materials, 2005
The purpose of this study was to compare the product profile of a Silorane based composite which polymerizes by a cationic ring opening process with the product profile of different methacrylate based restoratives.Four methacrylate based materials Filtek Z250, Filtek P60,Tetric ceram, Spectrum TPH and a Silorane based material were investigated with ...
Wolfgang, Weinmann, Christoph, Thalacker, Rainer, Guggenberger   +2 more
openaire   +2 more sources

Nanoindentation of dental composites

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2005
Abstract The intent of this project was to evaluate the elastic modulus and hardness of four composites with different fillers, a microfill, a hybrid, a dental resin cement, and a fiber filler, using nanoindentation. An indentation load of 0.001 N was used and 100 indents per specimen were taken.
openaire   +2 more sources

DENTAL COMPOSITION

2021
KLEE JOACHIM E, SZILLAT FLORIAN, KIRSCHNER JULIE, LALEVEE JACQUES   +3 more
  +9 more sources