Results 31 to 40 of about 17,874 (251)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

An overview of development and status of fiber-reinforced composites as dental and medical biomaterials

Acta Biomaterialia Odontologica Scandinavica, 2018
Fibr-reinforced composites (FRC) have been used successfully for decades in many fields of science and engineering applications. Benefits of FRCs relate to physical properties of FRCs and versatile production methods, which can be utilized.
Pekka K. Vallittu
doaj   +1 more source

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

A review of nano-composites

مجله دانشکده دندانپزشکی اصفهان, 2012
Introduction: Dental composite resins, as the name implies, are composite materials composed of organic and inorganic elements. The main components of dental composites are polymers, organic and inorganic filers, an initiator and an activator.
Mozhgan Rafizadeh, Mohammad Reza Moharreri, Kazem Khosravi, Farnaz Moshref-Javadi, Maryam Khoroushi   +4 more
doaj  

Properties of A Model Self-Healing Microcapsule-Based Dental Composite Reinforced with Silica Nanoparticles

Journal of Functional Biomaterials, 2022
Aim: The purpose of this study was to evaluate the mechanical properties of an experimental self-healing dental composite model (SHDC) composed of SiO2 nanoparticles with varying percentages of triethylene glycol dimethacrylate (TEGDMA) monomer and N,N ...
Khaled Abid Althaqafi, Abdulrahman Alshabib, Julian Satterthwaite, Nikolaos Silikas   +3 more
doaj   +1 more source

Controlling Grain Growth in Powder Bed Fusion of Yttria‐Stabilized Zirconia Using Femtosecond Lasers: Challenges and Methodological Insights

Advanced Engineering Materials, EarlyView.
Binder‐free laser powder bed fusion of 8YSZ with a femtosecond laser is used to map process windows linking scan strategy, heat accumulation, and grain growth. Time‐resolved thermography and simulations reveal thermal regimes that enable continuous, vitrified, and fine‐grained 8YSZ surface layers without absorptive additives and demonstrate ...
Markus Kühn, Sarah Kaden, Andrea Barz, Daniel Störzner, Jens Bliedtner, Andrés Fabián Lasagni   +5 more
wiley   +1 more source

Degradation effects of dietary solvents on microhardness and inorganic elements of computer-aided design/computer-aided manufacturing dental composites

BMC Oral Health
Background Computer-aided design/computer-aided manufacturing (CAD/CAM) dental composites were introduced with superior mechanical properties than conventional dental composites. However, little is known on effects of dietary solvents on microhardness or
Selva Malar Munusamy, Lee Ching Helen-Ng, Mohideen Salihu Farook   +2 more
doaj   +1 more source

Preparation and Characterization of Sodium Aluminum Silicate-Polymer Composites and Effects of Surface Roughness and Scratch Directions on Their Flexural Strengths

Frontiers in Materials, 2021
Although efforts have been put into the research in polymer-infiltrated ceramic network composites (PICNs), data are needed to understand the relationship between surface roughness and flexural strength. In this work, a novel dental restorative composite
Bencang Cui, Fengbo Sun, Qian Ding, Huining Wang, Yuanhua Lin, Yang Shen, Ming Li, Xuliang Deng, Xuliang Deng, Lei Zhang, Cewen Nan   +10 more
doaj   +1 more source

Digital Light Processing of Thermoplastic Poly(methyl methacrylate) Photoresin Combined With Solvent Vapor Smoothing

Advanced Engineering Materials, EarlyView.
A thermoplastic PMMA‐based photoresin enables high‐resolution DLP printing followed by solvent‐vapor smoothing. The treatment reduces staircase‐induced surface roughness from 2.33 µm to 129 nm and increases visible‐light transmittance from approximately 30% to 80%, providing a route toward transparent PMMA components for rapid prototyping and non ...
Rozhin Heydarpour, Yuanyuan Li, Sebastian Kluck, Afnan Quazzie‐Hauser, Bastian E. Rapp, Frederik Kotz‐Helmer   +5 more
wiley   +1 more source