Results 281 to 290 of about 1,171,659 (392)

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Understanding factors that influence the drug choice of prescribers: A Q‐methodology study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Therapeutic decision‐making often involves weighing several treatment options on the basis of, among other things, the disease profile, patient characteristics but also prescriber‐specific factors. This study investigated the factors influencing therapeutic decision‐making among prescribers and explores how these factors differ ...
Mariëlle G. Hartjes, Annelot E. F. Elsevier, Jan Willem Grijpma, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar   +5 more
wiley   +1 more source

Effectiveness of Nonpharmacological Behavioural Interventions in Managing Dental Fear and Anxiety among Children: A Systematic Review and Meta-Analysis. [PDF]

Healthcare (Basel)
Almarzouq SSFS, Chua H, Yiu CKY, Lam PPY.   +3 more
europepmc   +1 more source

Towards greener prescribing? Swedish general practitioners' support for policies to reduce pharmaceutical pollution

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing pharmaceuticals is essential to improve health, but it also has substantial environmental impact. This study investigated the extent to which Swedish general practitioners (GPs) are willing to integrate environmental aspects into treatment decisions and their opinions on policies to reduce pharmaceutical pollution.
Johanna Villén, Johanna Laux, Björn Wettermark, Sofia Kälvemark Sporrong, Marmar Nekoro, Helle Håkonsen   +5 more
wiley   +1 more source

A test of pre-exposure spacing and multiple context pre-exposure on the mechanisms of latent inhibition of dental fear: A study protocol. [PDF]

BMC Psychol
Geers AL, Seligman LD, Pituch KA, Colagiuri B, Marusak HA, Rabinak CA, Al-Ado SL, Turner N, Nedley M.   +8 more
europepmc   +1 more source

Bringing Small Devices, Giving Design Advice: Introducing Radiation Protection Practices in Greece via the IAEA's Visiting Professor Program**

Berichte zur Wissenschaftsgeschichte, EarlyView.
Abstract This paper examines how an International Atomic Energy Agency (IAEA) expert mission for technical assistance in the late 1950s to Greece was effectively transformed into a mission to achieve the IAEA′s central objective: to consolidate its position as the leading global authority on radiation protection. The study focuses on the work of Alfred
Loukas Freris
wiley   +1 more source

A study protocol testing pre-exposure dose and compound pre-exposure on the mechanisms of latent inhibition of dental fear. [PDF]

BMC Psychol
Geers AL, Seligman LD, Pituch KA, Colagiuri B, Marusak HA, Rabinak CA, Turner N, Al-Ado SL, Nedley M.   +8 more
europepmc   +1 more source

Biology wet lab e‐learning during and after the COVID‐19 pandemic: A review of student learning and experiences

Biochemistry and Molecular Biology Education, EarlyView.
Abstract The COVID‐19 pandemic began as a health crisis and quickly turned into an economic, social, and political crisis. It revealed the vulnerability of education systems to external changes and risks and challenged institutions and educators to transform and adapt at short notice. Following the COVID‐19 outbreak, one of the natural consequences was
Cristina Maglio, Manuela Williams, Alessandro Camponeschi   +2 more
wiley   +1 more source

Is there an association between head and neck cancer diagnosis and self-reported dental fear? A dual-center cross-sectional study. [PDF]

Natl J Maxillofac Surg
Maeda CY, Serrano RV, Campos L, Palma LF, Marcucci M.   +4 more
europepmc   +1 more source

Sacrificial strategy towards the formation of vascular‐like networks in volumetric tissue constructs

BMEMat, EarlyView.
This mini‐review highlights the latest progress in the sacrificial template‐enabled creation of patent vascular‐like networks, which can be incorporated into volumetric tissue constructs. Such microchannel networks can provide an immediate supply of nutrition and O2 to those cells residing next to the channels.
Christian Buckley, Rana Ibrahim, Felicia Giordano, Nuo Xu, Brandon Sems, Hongjun Wang   +5 more
wiley   +1 more source