Results 161 to 170 of about 73,396 (339)

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu   +11 more
wiley   +1 more source

BONE QUALITY IN PATIENTS RECEIVING ENDOSSEOUS DENTAL IMPLANTS

open access: bronze, 1994
Ira H. Orenstein   +4 more
openalex   +1 more source

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

open access: yesAdvanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong   +11 more
wiley   +1 more source

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du   +8 more
wiley   +1 more source

The Influence of First-Stage Mobility on the Osseointegration of Dental Implants

open access: hybrid, 1994
Frank R. Lauciello   +7 more
openalex   +1 more source

Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas

open access: yesAdvanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of the Dezhou donkey, encompassing 20 tissues and 275 050 cells, is constructed. Through cross‐species and cross‐tissue analyses, distinct transcriptional patterns in donkey sebocytes are identified.
Yu Tian   +11 more
wiley   +1 more source

Antler tine homologies and cervid systematics: A review of past and present controversies with special emphasis on Elaphurus davidianus

open access: yesThe Anatomical Record, Volume 306, Issue 1, Page 5-28, January 2023., 2023
Abstract Antlers are the most conspicuous trait of cervids and have been used in the past to establish a classification of their fossil and living representatives. Since the availability of molecular data, morphological characters have generally become less important for phylogenetic reconstructions.
Nicola S. Heckeberg   +2 more
wiley   +1 more source

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