Results 231 to 240 of about 287,405 (327)

Functional Analyses of SATB2 Variants Reveal Pathogenicity Mechanisms Linked With SATB2‐Associated Syndrome

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SATB2‐associated syndrome (SAS) is characterized by intellectual disability, neurodevelopmental disorders, cleft palate, and dental abnormalities. SAS is caused by variants in the special AT‐rich sequence‐binding protein 2 (SATB2), which encodes a transcription factor containing two CUT domains and a homeobox (HOX) domain.
Nao Ukita   +5 more
wiley   +1 more source

Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive‐compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform clinical decision‐making, allow for better‐tailored interventions, and avoid treatment failure.
Julia Bäckman   +39 more
wiley   +1 more source

Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Novel animal models showed the same pathological mechanism and imaging characteristics as those of patients with multiple trauma. Our model is useful for studying whether blocking or interfering with cytokine responses is beneficial in the treatment of multiple trauma patients.
Bing Zhang   +5 more
wiley   +1 more source

Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Laryngeal muscle evoked potentials (LMEPs) reflect the activation of laryngeal muscles induced by vagus nerve stimulation (VNS) via vagal Aα‐motor fibers. LMEP recordings are minimally invasive and provide a feasible, reliable method for assessing the integrity of the electrode‐nerve interface during experimental VNS in rodents.
Helen Bachmann   +3 more
wiley   +1 more source

Establishment of rat model for aspiration pneumonia and potential mechanisms

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Aspiration pneumonia was induced in Sprague Dawley rats by intratracheal instillation of hydrochloric acid (HCl, 1.5 μL/g.wt, pH = 1) followed by lipopolysaccharide (LPS, 20 μg/g.wt) after 1 h. The model reproduced hallmark features of acute lung injury, including histological lung damage, microvascular dysfunction, inflammation, hypoxemia, and ...
Hanbing Hu   +7 more
wiley   +1 more source

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