Results 181 to 190 of about 2,540,068 (366)
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Advanced Science, EarlyView.Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis +11 morewiley +1 more sourceThe Importance of Panoramic Radiography as an Auxiliary Instrument in Clinical and Legal Dental Practices
, 2016 Ana Amélia Barbieri, Renata de Albuquerque Cavalcanti Almeida, São Dds, Suely Carvalho Mutti Naressi, M. Fonseca Serpa Carvalho, Cesar Luiz, Mari Eli Leonelli de Moraes, Leonelli Elí, Ana Amélia, Barbieri Rua, Conselheiro Moreira, Ana Amlia, Barbieri Rua, Conselheiro Moreira, M Allatar, R Baughman, W Collett, Rqa Barros, Rcr Oka, Tsv Holmes, A Cavalcanti, P Bento, G Godoy, C Bissoli, Jcm Castilho, Medici Filho, E Moraes, L Moraes, Mel David, A, Brazil, A Buchner, Cmac Costa, A Madeiro, F Bandeira, Pasma Cunha, S Fenelon, R Glass, M Goldstein, D Sweet, R Wood, Acs Gonalves, Jlf Antunes, Y Hanaoka, A Ueno, K Minaguchi, M Kajiwara, Y Sato, M Oshida, Amsc Jcome, E Abdo, D Keith, J Kieser, W Laing, P Herbison, P Monsour, C Pinheiro, M Tostes, A Pinheiro, I Pretty, B Rothwell, R Silva, Dea Marinho, T Botelho, Phf Caria, F Brzin, Daruge Jnior, E, J Vicci, Ala Capelozza, A Warnick +70 moreopenalex +1 more sourceDiscovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract
Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu +15 morewiley +1 more sourceSingle‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region
Advanced Science, EarlyView.Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao +10 morewiley +1 more sourceA quantitative assessment of residual protein levels on dental instruments reprocessed by manual, ultrasonic and automated cleaning methods
BDJ, 2011 M. Vassey, C. Budge, T. Poolman, P. Jones, D. Perrett, N. Nayuni, P. Bennett, P. Groves, A. Smith, M. Fulford, P. Marsh, J. Walker, J. Sutton, N. Raven +13 moresemanticscholar +1 more source
