Results 41 to 50 of about 1,768,422 (288)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Analysis of thermal profiles on tooth structure and insert during one-piece or adapter-coupled ultrasonic insert use: an in vitro experimental study [PDF]

Restorative Dentistry & Endodontics
Objectives This in vitro study aimed to evaluate temperature variation on the external surface of mandibular molars and within ultrasonic inserts when using adapter-coupled versus one-piece inserts.
Gabriela Loewen Brotto, Bruno Monguilhott Crozeta, Bruno Marques-da-Silva, Alysson Nunes Diógenes, Emmanuel João Nogueira Leal da Silva, Flávia Sens Fagundes Tomazinho   +5 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Comparative Evaluation of Periodontal Instruments for the Detection of Subgingival Calculus

Oral
Background/Objectives: This study compared the capabilities of four periodontal assessment instruments (CP11 probe, WHO probe, explorer, and #11/12 explorer) to detect subgingival calculus and assess calculus morphology when used by dental hygienists ...
Mako Naniwa, Takako Yodogawa, Masayo Nakamura   +2 more
doaj   +1 more source

Ultrasonic Abrasion: An Alternative for Cavity Preparation [PDF]

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2007
Introduction: Restorative dentistry aims to repair damages caused by caries disease. Along the years, researchers have developed effective and less invasive methods with the goal of preserving the teeth from caries destruction. Therefore, the improvement
Áurea Simone Barrôso VIEIRA, Lívia Azeredo ANTUNES, Lucianne Cople MAIA, Laura Guimarães PRIMO   +3 more
doaj  

Rotary instrument system preferences in endodontic retreatment among dentists in Turkey [PDF]

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Objectives: This study aimed to evaluate dentists’ self-reported use of rotary instrument systems and related selection criteria during non-surgical endodontic retreatment in Turkey, and to identify demographic and professional factors associated with ...
Esma Fatima Delican, Emre Iriboz
doaj   +1 more source

Analysis of the characteristics of periodontal curettes used for scaling the roof of the furcation by manual versus digital method

Revista de Odontologia da UNESP, 2021
Introduction The treatment of periodontal disease in multiradicular teeth with furcation involvement is a challenge for dentists, with unpredictable results.
Larissa Porcaro SALOMÃO, Marcela Morgana Teixeira da SILVA, Alessandra Areas e SOUZA, Gabriela Alessandra da Cruz Galhardo CAMARGO, Eliane Marçon BARROSO, Elizangela Cruvinel ZUZA   +5 more
doaj   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

Adult oral health and dental visiting in Australia: results from the National Dental Telephone Interview Survey 2010 [PDF]

, 2013
This publication reports on the oral health, dental visiting and dental treatment needs of Australian adults as self-reported in the National Dental Telephone Interview Survey (NDTIS) 2010.
Jane Harford, Saima Islam, Harford, J.E., Islam, S.   +3 more
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