Results 161 to 170 of about 3,187,304 (383)

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

open access: yesAdvanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang   +8 more
wiley   +1 more source

216 Jewish Hospital of St. Louis [PDF]

open access: yes, 1966
https://digitalcommons.wustl.edu/bjc_216/1076/thumbnail ...

core   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

open access: yesAdvanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma   +9 more
wiley   +1 more source

Fourth annual Science in the House exhibition at the new parliament building [PDF]

open access: yes, 2015
Members of Parliament, the House of Representatives and researchers were in attendance at the 4th annual Science in the House exhibition in the New Parliament Building in Valletta at noon of Thursday 24th September 2015.
Magri, David C.   +2 more
core  

Deciphering Cell Type Abundance in Proteomics Data Through Graph Neural Networks

open access: yesAdvanced Science, EarlyView.
GraphDEC constructs pseudo bulk reference data using a mixup strategy, then learns low dimensional representations via autoencoders to model intra and inter dataset relationships. These are processed through a multi view adaptive neighborhood aware GNN, integrating reference, target, and joint graphs.
Zhiming Dai   +7 more
wiley   +1 more source

Spectrum, Spring 1991 [PDF]

open access: yes, 1991
Spectrum was a newsletter for students, faculty, staff and alumni of the Henry M.
Frankl, Spencer N.
core  

tRF‐5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Acute respiratory distress syndrome (ARDS) is a severe lung condition with limited treatments, often triggered by overactive endothelial cells (ECs). It is identified that macrophage‐derived secretory autophagosomes (MSAPs) exacerbate lung damage by activating EC function.
Xing‐xing Zhu   +17 more
wiley   +1 more source

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