Results 51 to 60 of about 407,117 (307)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

بررسی آلودگی میکروبی پروتز‏های متحرک آکریلی نو ساخته شده در لابراتوارهای دندانپزشکی شهر یزد (ایران) در سال 1388 [PDF]

Journal of Mashhad Dental School, 2011
مقدمه: با توجه به احتمال آلودگی‏های میکروبی پروتز‏های د‏هانی و به دلیل تماس آنها با بافت‏های د‏هان، بزاق و خون، امکان ایجاد عفونت متقاطع در بین کادر دندانپزشکی، پرسنل لابراتوار‏ها و سایر بیماران وجود دارد. در مورد افراد سالخورده، ضعیف و یا افراد دچار نقص
محمدحسین لطفی کامران, عباسعلی جعفری ندوشن, عباس فلاح تفتی, سید سجاد موسوی, مریم ساده, مرضیه بیگم مدرسی   +5 more
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Social Media in the Dental School Environment, Part B: Curricular Considerations [PDF]

, 2015
The goal of this article is to describe the broad curricular constructs surrounding teaching and learning about social media in dental education. This analysis takes into account timing, development, and assessment of the knowledge, skills, attitudes ...
Chambers, David, Donate-Bartfield, Evelyn, Karimbux, Nadeem, McAndrew, Maureen, Spallek, Heiko, Turner, Sharon P., Zarkowski, Pamela   +6 more
core   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Viability of the Digitalization of Dental Laboratory in Bacolod City

Philippine Social Science Journal, 2020
Dentistry has evolved from its origin to the present day, becoming almost entirely digitized and supervised. The digitalized dental laboratory saves time due to computer-aided design and computer-aided manufacture (CAD/CAM) technology, which will ...
Paul Brian S. Mendez, Rizalie N.E. Mibato   +1 more
doaj   +1 more source

Accuracy and precision of an intraoral scanner in complex prosthetic rehabilitations: an in vitro study [PDF]

, 2017
The main purpose of this study is to measure the accuracy and the precision of the intraoral optical scanner CS3500® (Carestream Dental LLC, Atlanta, USA) in complex clinical situations as full arch rehabilitations on impl ants.
BRAUNER, EDOARDO, DE ANGELIS, FRANCESCA, DI CARLO, Stefano, PICCOLI, Luca, PIGNATIELLO, GIUSEPPE, POMPA, Giorgio   +5 more
core  

Evidence that process simulations reduce anxiety in patients receiving dental treatment: randomized exploratory trial [PDF]

, 2011
Process simulations – mental simulations that ask people to imagine the process of completing a task – have been shown to decrease anxiety in students facing hypothetical or psychological threats in the short term.
Christopher J. Armitage, John G. Reidy, Nuttall N.M., Schwarzer R., Steele C.M.   +4 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source