Results 71 to 80 of about 29,343 (295)

The effect of framework fabrication technique on the fit accuracy of full arch screw retained implant supported prostheses

Saudi Dental Journal, 2022
Purpose: The purpose of this study was to compare the accuracy of fit of Co-Cr full arch screw-retained implant-supported fixed dental prosthesis fabricated among three different methods: conventional casting, milling, and additive manufacturing ...
Fellwa AlRasheed, Khalid AlWazzan
doaj   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Effect of Margin Designs on the Marginal Adaptation of Zirconia Copings

Acta Stomatologica Croatica, 2017
Objective: The aim of this in vitro study was to investigate the effect of Shoulder versus Chamfer margin design on the marginal adaptation of zirconia (Zr) copings.
Syed Rashid Habib, Mohammed Ginan Al Ajmi, Mohammed Al Dhafyan, Abdulrehman Jomah, Haytham Abualsaud, Mazen Almashali   +5 more
doaj   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Influence of polyurethane resin dies on the fit and adaptation of full veneer crowns

Indian Journal of Dental Research, 2015
Context: Polyurethane resin is a possible alternative to type IV dental stone for fabrication of indirect restorations however its dimensional accuracy is questionable.
Graeme R R Lillywhite, Fahim Vohra
doaj   +1 more source

CELLama: Foundation Model for Single Cell and Spatial Transcriptomics by Cell Embedding Leveraging Language Model Abilities

Advanced Science, EarlyView.
CELLama is created, a framework that harnesses language models to convert cellular data into “sentences” that represent gene expression and metadata, enabling a universal embedding of cells. Unlike most single‐cell foundation models, CELLama supports scalable analysis and offers flexible applications including spatial transcriptomics.
Jeongbin Park, Sumin Kim, Jiwon Kim, Dongjoo Lee, Sungwoo Bae, Haenara Shin, Daeseung Lee, Hongyoon Choi   +7 more
wiley   +1 more source

Effect of fitting procedures on the marginal gap of all-ceramic crowns: an in vitro study

Saudi Dental Journal
Marginal adaptation is a crucial determinant of dental restoration success, directly influencing longevity and clinical outcomes. This study investigated the impact of fitting procedures on the marginal adaptation of CAD/CAM-fabricated all-ceramic crowns.
Khalid A. Alwazzan, Adeeb M. Almotairi, Abdullah K. Alwazzan, Faisal A. Albesher, Feras E. Tawhari, Nawaf A. Alhumizi   +5 more
doaj   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Low shrinkage composite resins: influence on sealing ability in unfavorable C-factor cavities

Brazilian Oral Research, 2011
The present investigation observed the sealing ability of low shrinkage composite resins in large and deep cavities, placed and photocured in one increment.
Eliza Burlamaqui Klautau, Karina Kato Carneiro, Marcelo Figueiredo Lobato, Sissy Maria Mendes Machado, Mário Honorato Silva e Souza Junior   +4 more
doaj   +1 more source