Objectives. This study aimed to develop a gel with dentin-remineralizing properties, integrating nano-hydroxyapatite (nHA), sodium fluoride (NaF), and bioactive glass (BG). Materials and Methods. The enamel layer of 40 bovine incisors was removed.
Mohadese Asadi+3 more
doaj +1 more source
Effect of preoperative analgesics and cooled Lidocaine with Epinephrine on the anesthetic efficacy of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: A single-blind, randomized controlled trial [PDF]
Background: Treating mandibular molars with symptomatic irreversible pulpitis poses challenges, as achieving anaesthesia in “hot teeth” is difficult. Epinephrine aids anaesthesia by reducing blood absorption through local vasoconstriction.
Borugadda, Roopesh+5 more
core +2 more sources
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan+4 more
wiley +1 more source
Mass spectrometry-based metabolomics study of nicotine exposure in THP-1 monocytes
The tobacco alkaloid nicotine is known for its activation of neuronal nicotinic acetylcholine receptors. Nicotine is consumed in different ways such as through conventional smoking, e-cigarettes, snuff or nicotine pouches.
Silvio Uhlig+7 more
doaj +1 more source
The amazing spectrum of light – LASER [PDF]
“In right light at right time everything is extraordinary”- says Aaron Rose. This is very true with respect to lasers. Discovery of lasers from the spectrum of light has revolutionized the technology in many fields.
Gosavi, Siddharth Y+4 more
core +2 more sources
The temporary transition of macrophages from a pro‐inflammatory phenotype of macrophages (M1) to an anti‐inflammatory phenotype of macrophages (M2) is crucial for tissue repair and regeneration processes. Bacterial outer membrane vesicles (OMVs) are utilized as a “trojan horse” for specific M1 macrophage‐targeting and anti‐inflammatory drug delivery ...
Donglin Cai+9 more
wiley +1 more source
Evaluation of Marginal Sealing in Adhesives Restorations After the Use of a Papain Gel [PDF]
Objective: Evaluate the sealing conditions of adhesive restorations after the chemomechanical removal of carious tissue with a papain gel (Papacarie®) and after the traditional method of caries removal utilizing rotatory instruments.
Natália Costa ARAÚJO+3 more
doaj
Evaluation of the accuracy of working length determination and automatic apical reverse function accuracy of endodontic rotary motor integrated apex locator: an in-vitro study [PDF]
Background: The outcome of a Root canal therapy depends upon complete cleaning of the root canal system without damaging periapical integrity. Accurate determination of working length determination is essential.
K, Madhu Varma+5 more
core +2 more sources
A bioengineered skin equivalent composed of electrospun poly(ε‐caprolactone) (PCL) and the bioactive peptide Fmoc‐FRGD is developed for severe burn treatment. This scaffold promotes full‐thickness skin regeneration by supporting cellular adhesion and integration. In‐vitro and in‐vivo studies show enhanced mechanical stability, accelerated wound closure,
Dana Cohen‐Gerassi+11 more
wiley +1 more source
Crystal Structure Studies of Human Dental Apatite as a Function of Age [PDF]
Studies of the average crystal structure properties of human dental apatite as a function of the tooth-age in the range of 5-87 years are reported. The crystallinity of the dental hydroxyapatite decreases with the tooth-age. The a-lattice constant that is associated with the carbonate content in carbonate apatite decreases with the tooth-age in a ...
arxiv