Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
Advanced Science, EarlyView.Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang +17 more
wiley +1 more source
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
, 1942 A directory of licensed dentists and dental hygienists registered in Kansas. Dental hygienists were added to the directory starting with the 1935 List Issued by Kansas State Board of Dental Examiners, 1927-1943; issued by Kansas State Dental Board, 1945 ...
Kansas State Board of Dental Examiners
core +1 more source
Depth of Curve of Spee in Relation to Craniofacial and Dental Morphology. [PDF]
Acta Stomatol CroatMarjanović M +4 more
europepmc +1 more source
A proposed terminology for the dentition of gomphodont cynodonts and dental morphology in Diademodontidae and Trirachodontidae. [PDF]
PeerJ, 2019 Hendrickx C, Abdala F, Choiniere JN.
europepmc +1 more source
Dual‐Targeted Biomimetic MoSe2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration
Advanced Science, EarlyView.A dual‐targeting biomimetic nanozyme, MoSe2@SPMM, selectively targets Staphylococcus aureus and oxidatively stressed macrophages. Near‐infrared activation couples contact‐enhanced photothermal bacterial eradication with reactive oxygen species scavenging to disrupt the pathogenic–immunological amplification loop.
Minghao Zhou +7 more
wiley +1 more source
The impact of artificial intelligence evolution on the dental morphology sculpting education. [PDF]
J Dent SciLin WC, Cheng FC, Huang YS, Chiang CP.
europepmc +1 more source
Fossil evidence of evolutionary convergence in juvenile dental morphology and upper canine replacement in sabertooth carnivores. [PDF]
Ecol Evol, 2019 Wysocki MA.
europepmc +1 more source
Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli
Advanced Science, EarlyView.Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma +18 more
wiley +1 more source
Linking facial typology to dental morphology and gingival characteristics: a cross-sectional study. [PDF]
BMC Oral HealthOruba Z +7 more
europepmc +1 more source