Results 91 to 100 of about 1,783,328 (341)

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Load-bearing capacity of novel resin-based fixed dental prosthesis materials

, 2018
To evaluate the influence of different materials on the load-bearing-capacity of inlay-retained fixed-dental-prosthesis (FDP). Ten types of FDPs were evaluated (n=7/group): Group PEEK: CAD-CAM polyetheretherketone (PEEK-TechnoMed), Group RC, made of ...
Cekic-Nagas, Isil and Egilmez, Ferhan and Ergun, Gulfem and Vallittu, Pekka Kalevi and Lassila, Lippo Veli Juhana
core   +2 more sources

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

FiltekTM Silorane and FiltekTM Supreme XT resins: tissue reaction after subcutaneous implantation in isogenic mice [PDF]

, 2011
The aim of this study was to evaluate the tissue compatibility of a silorane-based resin system (FiltekTM Silorane) and a methacrylatebased nanoparticle resin (FiltekTM Supreme XT) after implantation in the subcutaneous connective tissue of isogenic ...
Nelson Filho, Paulo, Gatón Hernández, Patrícia, Raquel A. B. Silva, CASTAÑEDA, Esther Ruiz De, González Rodríguez, Encarnación, Queiroz, Alexandra Mussolino de, GATON-HERNÁNDEZ, Patrícia, RODRIGUEZ, Encarnación Gonzalez, Esther Ruiz De Castañeda, Paulo Nelson-Filho, NELSON-FILHO, Paulo, QUEIROZ, Alexandra M., Alexandra M. Queiroz, Alberto Consolaro, Léa A. B. Silva, Encarnación Gonzalez Rodriguez, Ruiz de Castañeda, Esther, Silva, Léa Assed Bezerra da, SILVA, Raquel A. B., Consolaro, Alberto, Silva, Raquel Assed Bezerra da, SILVA, Léa A. B., Patrícia Gaton-Hernández   +22 more
core   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Minimally Invasive Direct Approach for Severe Dental Fluorosis: Balancing Aesthetics and Quality of Life

Clinical Case Reports
Dental fluorosis, a condition caused by excessive fluoride intake during enamel formation, can significantly affect patients' quality of life due to aesthetic concerns.
Rosa Guyonvarch, Julia Estivals, Olivia Kérourédan   +2 more
doaj   +1 more source

Restorasi resin komposit dengan free-hand layering technique

Composite resin restoration with free-hand layering technique

Jurnal Kedokteran Gigi Universitas Padjadjaran, 2017
Pendahuluan: Restorasi gigi pasca perawatan endodontik merupakan bagian integral dari kunci keberhasilan pengobatan. Beberapa faktor dipertimbangkan untuk keberhasilan restorasi gigi pasca endodontik seperti rasio antara mahkota dan akar, dan jaringan ...
Danica Anastasia, Bebbi Arisya Kesumaputri   +1 more
doaj   +1 more source

Dental resin composites generate microparticles and impact on gingival keratinocytes—In vitro study [PDF]

European Journal of Oral Sciences, EarlyView.
Abstract Along with our increased understanding of the spread of microplastic pollution, the awareness of microparticle release from medical and dental materials has increased. Still, their effects on human health are largely unknown. As the use of resin composite materials in dentistry continues to increase, it is essential to understand the formation
Ella Pullinen, Saara V. Sirkiä, Johan O. Nyman, Pekka Kalevi VALLITTU, Vuokko Loimaranta   +4 more
openalex   +2 more sources