Results 141 to 150 of about 84,658 (321)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Journal of Periodontology, Volume 93, Issue 12, Page 1827-1847, December 2022., 2022
Abstract Background The use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), and implant site development (ISD). The present systematic review aimed to analyze the effect of autologous blood‐derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet‐derived growth factor‐BB (rhPDGF ...
Fernando Suárez‐López del Amo, Alberto Monje   +1 more
wiley   +1 more source

Replacement of Avulsed Tooth in the Esthetic Zone Using Chair-side Fabricated Resin Composite Pontic: A Case Report

Journal of the Bahrain Medical Society
Avulsion of permanent teeth is a complex traumatic dental injury (TDI) where a tooth is completely displaced out of its socket without fracturing.
Sufyan Nisar Ahmed Ansari, AbdulAziz Osama Al Qahtani   +1 more
doaj   +1 more source

Restoration of human tooth enamel

BMEMat, EarlyView.
Human tooth enamel has remarkable properties but lacks self‐repair ability. Existing restorative materials cannot fully replicate enamel's microstructure and function, resulting in low restorative efficiency. This review summarizes the formation process and characteristics of enamel, and current restorative materials and future research directions are ...
Hanlin Liu, Bo Li, Mingrui Gao, Yangbei Li, Xiuyi Yang, Fengshi Li, Zhi Cai, Yi Liu, Shaojia Liu, Hewei Zhao, Lin Guo   +10 more
wiley   +1 more source

American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice

Journal of Periodontology, Volume 93, Issue 12, Page 1763-1770, December 2022., 2022
Abstract A biologic is a therapeutic agent with biological activity that is administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become a core component of contemporary periodontal practice. However, some questions remain about their safety, indications, and effectiveness in specific clinical ...
Gustavo Avila‐Ortiz, Jeanne Ambruster, Shayan Barootchi, Leandro Chambrone, Chia‐Yu Chen, Douglas R. Dixon, Maria L. Geisinger, William V. Giannobile, Katie Goss, John C. Gunsolley, Rick H. Heard, David M. Kim, George A. Mandelaris, Alberto Monje, Marc L. Nevins, Angela Palaiologou‐Gallis, Paul S. Rosen, E. Todd Scheyer, Fernando Suarez‐Lopez del Amo, Lorenzo Tavelli, Diego Velasquez, Hom‐Lay Wang, Brian L. Mealey   +22 more
wiley   +1 more source

Expertise‐inspired artificial intelligence pipeline for clinically applicable reconstruction of tooth‐centric radial planes: Development and multicenter validation

BMEMat, EarlyView.
The expertise‐inspired AI pipeline demonstrates significant clinical utility for rapid and precise analysis of dento‐maxillofafcial CBCT and benefits for intelligent oral health management. Abstract Owing to the tooth‐centered nature of most oral diseases, the tooth‐centric radial plane of cone‐beam computed tomography (CBCT) depicts the anatomical and
Zhuohong Gong, Gengbin Cai, Jiayang Zeng, Beichen Wen, Hengyi Liu, Jiahong Lin, Xiaofei Meng, Peisheng Zeng, Jiamin Shi, Rui Xie, Yang Yu, Yin Xiao, Mengru Shi, Ruixuan Wang, Zetao Chen   +14 more
wiley   +1 more source

Prevalence and pattern of restorations on permanent molar teeth among adult dental patients [PDF]

Dental, Oral and Craniofacial Research, 2019
J.E. Enabulele, AO Ehizele
openaire   +1 more source

A clinical dilemma: Performing or avoiding root instrumentation in the treatment of the acute phase of endodontic‐periodontal lesions? A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background This study presents the diagnois, management, and tissue response to an acute periodontal lesion with deep pocketing affecting a maxillary central incisor in a young patient devoid of caries or a history of periodontitis. Methods Clinical and radiographic examinations facilitated the diagnosis of the pathology as an endoperiodontal ...
Riccardo Pace, Riccardo Di Gianfilippo, Debora Franceschi, GiovanPaolo Pini Prato   +3 more
wiley   +1 more source

Treatment Planning Challenges In Case Of Root Proximity: An Interdisciplinary Approach

Frontiers in Dentistry, 2022
Root proximity is defined as a situation where the distance between the roots of adjacent teeth on radiographs is ≤1.0 mm. This important situation should be detected by clinicians before definitive restorative treatments and they should be well aware ...
Azam Sadat Mostafavi, Negin Yaghoobi
doaj  

Effect of suturing in root coverage via coronally advanced flaps: A systematic review

Clinical Advances in Periodontics, EarlyView.
Abstract Background To analyze the evidence about the influence of the suturing technique and material in terms of the percentage of mean root coverage (%MRC) following root coverage therapy in teeth diagnosed with single/localized gingival recession defects (GRD) via a monolaminar coronally advanced flap. Methods The protocol of this systematic review
Alina Ariceta, Leandro Chambrone, Sandra Stuhr, Emilio Couso‐Queiruga   +3 more
wiley   +1 more source