Results 61 to 70 of about 1,731,829 (296)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Selective Caries Removal in Permanent Teeth (SCRiPT) for the treatment of deep carious lesions: a randomised controlled clinical trial in primary care

BMC Oral Health, 2021
Background Dental caries is one of the most prevalent non-communicable disease globally and can have serious health sequelae impacting negatively on quality of life.
Jan E. Clarkson, Craig R. Ramsay, David Ricketts, Avijit Banerjee, Chris Deery, Thomas Lamont, Dwayne Boyers, Zoe Marshman, Beatriz Goulao, Katie Banister, David Conway, Bhupinder Dawett, Sarah Baker, Andrea Sherriff, Linda Young, Marjon van der Pol, Graeme MacLennan, Ruth Floate, Hazel Braid, Patrick Fee, Mark Forrest, Jill Gouick, Fiona Mitchell, Ekta Gupta, Riz Dakri, Jennifer Kettle, Tina McGuff, Katharine Dunn   +27 more
doaj   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Restored Primary Molars in a Group of Children Presenting to the Pediatric Department of College of Dentistry, University of Baghdad in 2014-2015

Journal of Dental School, 2019
Objectives This study aimed to assess the distribution and classification of restored primary molars according to the tooth type, gender, jaw, quadrant, filling material and G.V. Black classification in children presenting to the Department of Pediatric
Zainab Juma Jafar, Dina Akram
doaj   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Comparative Strength Study of Indirect Permanent Restorations: 3D-Printed, Milled, and Conventional Dental Composites

Clinics and Practice
Background/Objectives: Limited research has been performed to assess the strength of resin-bonded 3D-printed restorations. Based on that, this study investigates the impact of different manufacturing methods on the fracture load of indirect composite restorations (ICRs) following an aging process.
João Paulo Mendes Tribst, Adelheid Veerman, Gabriel Kalil Rocha Pereira, Cornelis Johannes Kleverlaan, Amanda Maria de Oliveira Dal Piva   +4 more
openaire   +4 more sources

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Prognostic Management Of Chronic Periapical Periodontitis In Anterior Teeth

International Dental Journal
Introduction: A 3-years old boy reported to Orange Dental for Kids with a series of dental problems including root canal therapy,extraction and fixed partial denture .
Chen Xinpeng
doaj   +1 more source

Restorative procedures and extractions of permanent teeth in Brazil’s public dental services (2008–2024)

Journal of Health & Biological Sciences
Objective: to assess the proportion between restorative procedures and extractions of permanent teeth (R:E) in Brazil's public dental services from 2008 to 2024. Method: a time series was constructed within this timeframe using data from the ambulatory productivity reports.
Paulo Ribeiro de Carvalho Gomes, Amanda Negreiros Arrais, Hitalo Costa Delmondes, Luila De Matos Andrade, Mariana Paulino Cruz, Pedro Henrique Benedicto Santos, Daniella Dos Anjos Rodrigues Barauna, Ricardo Barbosa Lima   +7 more
openaire   +1 more source