Results 111 to 120 of about 1,080,047 (298)

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang   +5 more
wiley   +1 more source

CERAMICS FOR DENTAL RESTORATIONS - AN INTRODUCTION

open access: yesDyna, 2010
Las cerámicas dentales son el material de elección para restauración oral debido a características como adecuada estética, elevada resistencia a la fractura y gran estabilidad química.En la actualidad, los profesionales de la Odontología tienen a su disposición una gran cantidad de sistemas cerámicos de restauración que presentan pequeñas o grandes ...
ARANGO SANTANDER, SANTIAGO   +4 more
openaire   +3 more sources

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

open access: yesAdvanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan   +10 more
wiley   +1 more source

Favorable periodontal surgical outcome of a severe endodontic-periodontal lesion

open access: yesAsian Journal of Surgery, 2023
Xiang-Zhen Yan   +3 more
doaj   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

open access: yesAdvanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie   +11 more
wiley   +1 more source

Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis

open access: yesJournal of Nanobiotechnology
Temporomandibular joint osteoarthritis (TMJOA) is a multifaceted degenerative disease characterized by progressive cartilage degradation, chronic pain, and functional limitations of the TMJ, significantly affecting patients’ quality of life.
Xiaofeng Hu, Jian Xie, Jiansheng Su
doaj   +1 more source

The Dental review.

open access: yes
Founded in 1916 as the School of Dentistry. Merged with the College of Dental and Oral Surgery of New York in 1923 to form the School of Dental and Oral Surgery.
Columbia University. College of Dental Medicine.   +1 more
core  

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

open access: yesAdvanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao   +5 more
wiley   +1 more source

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