Results 141 to 150 of about 105,338 (335)

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

open access: yesAdvanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong   +17 more
wiley   +1 more source

Bone construction surgery: A case report using recombinant human platelet‐derived growth factor‐BB

open access: yesClinical Advances in Periodontics, Volume 12, Issue 4, Page 262-269, December 2022., 2022
Abstract Background The position and condition of bone largely sets the stage for functional and esthetic implant success. In bone construction surgery, creating a sustainable functional matrix is complex, but necessary, to enable long‐term mechanotransduction and maintenance of soft tissue support.
George A. Mandelaris, Bradley DeGroot
wiley   +1 more source

Efeitos do acondicionamento de uma porcelana dentária em meio de saliva artificial na resistência mecânica e previsão do tempo de vida Effects of artificial saliva storage on flexural strength and lifetime prediction of a dental porcelain

open access: yesCerâmica, 2009
Verificou-se o efeito do acondicionamento em saliva artificial na resistência à flexão e no tempo de vida de uma porcelana feldspática dentária. Os espécimes na forma de disco foram preparados por sinterização, usinagem e polimento e ensaiados pelo ...
H. N. Yoshimura   +3 more
doaj   +1 more source

Scanning acoustic microscopy study of titanium-ceramic interface of dental restorations [PDF]

open access: bronze, 1998
Russell R. Wang   +2 more
openalex   +1 more source

Optimizing Anterior Implant Outcome Immediately After Implant Placement and Grafting by Using Patient’s Extracted Teeth: A Case Report [PDF]

open access: yes, 2017
Optimizing anterior implant outcome using patient’s extracted teeth. Successful implant treatment in the anterior maxilla is predicated on providing a functional and esthetically acceptable outcome.
Banez, Jay Darryl   +3 more
core   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

open access: yesAdvanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen   +12 more
wiley   +1 more source

The Effect of Dental Implant Restoration on the Biomechanics of the Temporomandibular Joint in Patients with Posterior Tooth Loss: A Pilot Study

open access: yesBioengineering
Currently, controversy persists over whether dental implant restoration exacerbates or alleviates temporomandibular disorders (TMDs). This study aimed to analyze the impact of dental implant restoration on the biomechanics of the temporomandibular joint (
Yuanli Zhang   +8 more
doaj   +1 more source

M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1hi Neutrophils to Enhance Inflamed Bone Regeneration

open access: yesAdvanced Science, EarlyView.
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao   +7 more
wiley   +1 more source

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

open access: yesAdvanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu   +6 more
wiley   +1 more source

Effect of 3D-printing assisted micro-osteoperforations on the rate of canine retraction: a clinical investigation

open access: yesBMC Oral Health
Objectives More time is often needed for adult orthodontic patients compared with juvenile counterparts due to lower tissue vitality. In some cases, the prolonged orthodontic treatment may cause a series of problems, such as enamel demineralization ...
Yangyifan Zhou   +5 more
doaj   +1 more source

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