Results 141 to 150 of about 105,338 (335)
Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong+17 more
wiley +1 more source
Bone construction surgery: A case report using recombinant human platelet‐derived growth factor‐BB
Abstract Background The position and condition of bone largely sets the stage for functional and esthetic implant success. In bone construction surgery, creating a sustainable functional matrix is complex, but necessary, to enable long‐term mechanotransduction and maintenance of soft tissue support.
George A. Mandelaris, Bradley DeGroot
wiley +1 more source
Verificou-se o efeito do acondicionamento em saliva artificial na resistência à flexão e no tempo de vida de uma porcelana feldspática dentária. Os espécimes na forma de disco foram preparados por sinterização, usinagem e polimento e ensaiados pelo ...
H. N. Yoshimura+3 more
doaj +1 more source
Scanning acoustic microscopy study of titanium-ceramic interface of dental restorations [PDF]
Russell R. Wang+2 more
openalex +1 more source
Optimizing Anterior Implant Outcome Immediately After Implant Placement and Grafting by Using Patient’s Extracted Teeth: A Case Report [PDF]
Optimizing anterior implant outcome using patient’s extracted teeth. Successful implant treatment in the anterior maxilla is predicated on providing a functional and esthetically acceptable outcome.
Banez, Jay Darryl+3 more
core +1 more source
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen+12 more
wiley +1 more source
Currently, controversy persists over whether dental implant restoration exacerbates or alleviates temporomandibular disorders (TMDs). This study aimed to analyze the impact of dental implant restoration on the biomechanics of the temporomandibular joint (
Yuanli Zhang+8 more
doaj +1 more source
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao+7 more
wiley +1 more source
Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu+6 more
wiley +1 more source
Objectives More time is often needed for adult orthodontic patients compared with juvenile counterparts due to lower tissue vitality. In some cases, the prolonged orthodontic treatment may cause a series of problems, such as enamel demineralization ...
Yangyifan Zhou+5 more
doaj +1 more source