Results 141 to 150 of about 1,314,423 (339)

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

open access: yesAdvanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang   +9 more
wiley   +1 more source

Favorable periodontal surgical outcome of a severe endodontic-periodontal lesion

open access: yesAsian Journal of Surgery, 2023
Xiang-Zhen Yan   +3 more
doaj   +1 more source

Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis

open access: yesJournal of Nanobiotechnology
Temporomandibular joint osteoarthritis (TMJOA) is a multifaceted degenerative disease characterized by progressive cartilage degradation, chronic pain, and functional limitations of the TMJ, significantly affecting patients’ quality of life.
Xiaofeng Hu, Jian Xie, Jiansheng Su
doaj   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

open access: yesAdvanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin   +13 more
wiley   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

open access: yesAdvanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou   +6 more
wiley   +1 more source

Evaluation of Die Trim Morphology Made by CAD-CAM Technology [PDF]

open access: yes, 2017
Statement of problem The die contour can affect the emergence profile of prosthetic restorations. However, little information is available regarding the congruency between a stereolithographic (SLA) die and its corresponding natural tooth.
Agrawal, Pratiksha   +3 more
core   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

open access: yesAdvanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou   +7 more
wiley   +1 more source

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