Results 241 to 250 of about 71,499 (301)

Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy

open access: yesMovement Disorders, EarlyView.
Abstract Background Clinical progression rate is the typical primary endpoint measure in progressive supranuclear palsy (PSP) clinical trials. Objectives This longitudinal multicohort study investigated whether baseline clinical severity and regional brain atrophy could predict clinical progression in PSP–Richardson's syndrome (PSP‐RS).
Andrea Quattrone   +424 more
wiley   +1 more source

Plant defense strategies: The dual armor of disease resistance and tolerance

open access: yesNew Plant Protection, EarlyView.
Plants employ dual strategies against pathogens: Resistance limits invasion via immune responses, whereas tolerance mitigates damage to sustain growth—together enhancing survival under infections. Abstract Pathogen infections pose a significant threat to plant health, global food security, and ecosystems.
Zhijuan Tang   +3 more
wiley   +1 more source

Succinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway

open access: yesPediatric Discovery, EarlyView.
Succinate promotes macrophage to the M1 phenotype in the mouse mononuclear macrophage leukemia cells (Raw264.7 cells) and neonatal mice with NEC. Succinate activates the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) pathway via succinate recepter 1 (SUCNR1), promoting M1 polarization of NEC intestinal macrophages.
Sha Liu   +6 more
wiley   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said   +10 more
wiley   +1 more source

Effect of radiation therapy on the dentin bond strength of a universal adhesive. [PDF]

open access: yesBMC Oral Health
Saikaew P   +10 more
europepmc   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

open access: yesSmall, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen   +7 more
wiley   +1 more source

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