Results 81 to 90 of about 21,573 (262)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

Expert consensus: Prevention and treatment of dental implant biological complications [PDF]

Kouqiang yixue
Dental implantology has developed rapidly for over half a century, since pure titanium(99.7%) dental cylindrical threaded implants were exploited and osseointegration was introduced in 1960s by Prof. Brånemark.
WANG Xing, WANG Liping, WANG Qintao, SHU Rong, XUAN Dongying, WU Yiqun, QIU Lixin, ZOU Derong, SONG Yingliang, CHEN Jiang, XU Yan, ZHANG Jincai, SU Yucheng, GE Linhu, XIE Yufeng
doaj   +1 more source

Evaluating the Trends for Restorative Treatment, Reasons and Management of Failures in General Dental Practices of Hail Region, Saudi Arabia

Dental Research and Management, 2019
Aim: The study aims to identify the common causes of performing restoration of teeth in General Dental Practice (GDP). Analyze the common reasons for restoration failure, the material used in the management of restoration repair/replacement in Hail, Saudi Arabia.
Abdullah Muteb Alanazi, Rashid Iqbal Mian, Muteb Sayer Alshammari, Ibrahim Khalil AL Ibrahim, Fahad Abdulrahman Alnasrallah, Ahad Sayer Alshammari   +5 more
openaire   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Retention failures in cement- and screw-retained fixed restorations on dental implants in partially edentulous arches: A systematic review with meta-analysis

The Journal of Indian Prosthodontic Society, 2018
This systematic review aimed to evaluate retention failures in cement- and screw-retained fixed restorations on dental implants in partially edentulous arches.The relevant articles were retrieved from MEDLINE (PubMed), Cochrane Library, and EBSCO electronic databases for articles published from January 1995 to January 2016 and were restricted to ...
Jatin K Jain, Rajesh Sethuraman, Sameer Chauhan, Piyush Javiya, Shreya Srivastava, Rutvik Patel, Bhagyashri Bhalani   +6 more
openaire   +3 more sources

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Visualization of interfacial adhesive defects at dental restorations with spectral domain and polarization sensitive optical coherence tomography

Current Directions in Biomedical Engineering, 2018
Restoration loss based on interfacial adhesive defects and associated caries at the restoration margin are the main causes for invasive replacement of dental restorations.
Tetschke Florian, Golde Jonas, Walther Julia, Kirsten Lars, Koch Edmund, Hannig Christian, Rüger Claudia, Schneider Hartmut, Haak Rainer   +8 more
doaj   +1 more source