Results 141 to 150 of about 1,709,188 (241)

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

open access: yesArthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel   +12 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

open access: yesHepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario   +12 more
wiley   +1 more source

The Dental review.

open access: yes
Founded in 1916 as the School of Dentistry. Merged with the College of Dental and Oral Surgery of New York in 1923 to form the School of Dental and Oral Surgery.
Columbia University. College of Dental Medicine.   +1 more
core  

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

open access: yesArthritis &Rheumatology, EarlyView.
Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim   +14 more
wiley   +1 more source

Advances in Regenerative Dentistry: From Biological Mechanisms to Clinical Translation. [PDF]

open access: yesLife (Basel)
Ramirez-Velasquez M   +3 more
europepmc   +1 more source

Ethical challenges of emerging anatomical technologies in UK public engagement

open access: yesAnatomical Sciences Education, EarlyView.
Emergent technologies are increasingly used in anatomical education and public engagement. They expand access and reduce reliance on physical human tissue, but also introduce ethical challenges relating to consent, dignity, representation, transparency, and commercialization.
Lucy E. Hyde   +3 more
wiley   +1 more source

Anodal Transcranial Direct Current Stimulation Improves Social Behavior Alongside Neuroplastic Changes in a Tsc2+/− Rat Model of Autism Spectrum Disorder

open access: yesAutism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by altered synaptic connectivity and network organization, resulting in profound impairments in social communication and interaction. Transcranial direct current stimulation (tDCS) represents a promising approach to modulate maladaptive plasticity associated with ASD;
Antonia Ramme   +9 more
wiley   +1 more source

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