Results 231 to 240 of about 22,047 (321)

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

open access: yesAdvanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma   +10 more
wiley   +1 more source

Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis

open access: yesAdvanced Science, EarlyView.
Sleep deprivation (SD) exacerbates ligature‐induced periodontitis (LIP) through the trigeminal nerve‐periodontal neuroimmune pathway mediated by the acetylcholinesterase (AChE)‐acetylcholine (ACh)‐α7 nicotinic receptor (α7nAChR) axis. While electroacupuncture (EA) alleviates the condition of LIP combined with SD by activating the α7nAChR.
Kehao Liu   +13 more
wiley   +1 more source

SARS-CoV-2 Did Not Spread Through Dental Clinics During the COVID-19 Pandemic in Japan. [PDF]

open access: yesInfect Dis Rep
Tsubura Y   +15 more
europepmc   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

open access: yesAdvanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li   +7 more
wiley   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

open access: yesAdvanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang   +32 more
wiley   +1 more source

The association between dental therapy timelines and osteoradionecrosis: a nationwide population-based cohort study

open access: yesClinical Oral Investigations, 2019
Yi-Fang Huang   +4 more
semanticscholar   +1 more source

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