Results 111 to 120 of about 6,257,475 (333)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Rancangan Sistem Informasi Penilaian Praktikum Pelayanan Asuhan Keperawatan Gigi Untuk Menunjang Obyektifitas Penilaian Praktik Mahasiswa (Studi di Jurusan Keperawatan Gigi Politeknik Kesehatan Kementerian Kesehatan Bandung) [PDF]

, 2016
Universitas Diponegoro Fakultas Kesehatan Masyarakat Program Studi Magister Ilmu Kesehatan Masyarakat Konsentrasi Sistem Informasi Manajemen Kesehatan 2014 ABSTRAK Deru Marah Laut Rancangan Sistem Informasi Penilaian Praktikum ...
Adi, Kusworo, Laut, Deru Marah, Purnami, Cahya Tri   +2 more
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Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

The Academy of Dental Materials: Providing roots and wings. [PDF]

, 2019
ObjectivesThe long history of the Academy of Dental Materials (ADM) is documented with its strategies (a) to rapidly communicate science among its members, (b) to establish special awards to stimulate new science, and (c) to develop new dental materials ...
Bayne, Stephen C, Marshall, Grayson W, Marshall, Sally J   +2 more
core   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Can programme theory be used as a 'translational tool’ to optimise health service delivery in a national early years’ initiative in Scotland: a case study [PDF]

, 2013
Background Theory-based evaluation (TBE) approaches are heralded as supporting formative evaluation by facilitating increased use of evaluative findings to guide programme improvement.
A Blamey, A Cameron, B Glaser, C Beeston, C Carroll, CLS Coryn, DL Stufflebeam, H Sullivan, JB Cousins, JD Birckmayer, Jennifer Eaves, JP Connell, K Johnson, K Sielbeck-Bowen, L Bonner, LJ Damschroder, LMD Macpherson, M Barnes, M Bracht, M Carroll, M Mackenzie, M Mackenzie, M Mackenzie, M Page, M Scriven, MM Mark, MP Eccles, MQ Patton, P Craig, PJ Rogers, R Pawson, R Renger, RE Keith, RG O’Sullivan, S Carvalho, S Donaldson, S Donaldson, S Government, S Hawkins, S Ledermann, SC Funnell, Scottish Executive, Wendy Gnich   +42 more
core   +2 more sources

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Early Head Start Participants, Programs, Families, and Staff in 2005 [PDF]

, 2006
This fact sheet reviews the 2005 Program Information Reports (PIR) data for the Early Head Start program, which serves children under age 3 and pregnant women. In 2005, Early Head Start continued to provide vital services to a diverse group of low-income
Katie Hamm
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Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

The Value of Extra Benefits Offered by Medicare Advantage Plans in 2006 [PDF]

, 2008
Examines the out-of-pocket savings for average enrollees of private fee-for-service (PFFS) and other Medicare Advantage plans, compared to what they would pay under original Medicare, plus the value of additional services such as dental or vision ...
Mark Merlis
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