Results 121 to 130 of about 108,564 (308)

A novel bioactive nano-composite: synthesis and characterisation with potential use as dental restorative material [PDF]

, 2009
PhDIt is desirable for a dental restorative material to have bioactive and bonding properties. This study focuses on the synthesis of a covalently-linked polyurethane/nanohydroxyapatite (PU/nHA) composite and evaluates its chemical, physical, thermal ...
Khan, Abdul Samad
core  

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

An analysis of preferred appointment confirmation methods as it correlates to patient age groups and its effect on dental recall appointment failures [PDF]

, 2009
Includes bibliographical ...
Derfus, Stephanie J.
core  

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

On the mechanical behaviour of human tooth structures: An application of the finite element method of stress analysis [PDF]

, 1975
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The Finite Element Method of stress analysis is employed in axisymmetric, two and three-dimensional forms, to investigate the mechanical behaviour of dental
Wright, KWJ
core  

Influence of post design and elastic modulus mismatch between dentin and post-core on stress distribution in endodontically treated teeth: a finite element analysis study [PDF]

Background: ParaPost Fiber Posts are made to use resin-based cement and core build-up materials to provide an optimal Monoblock between the dentin-post-crown, resulting in one cohesive restoration.
Yalamanchi, Anusha, Sirigam, Sharmista Reddy, Reddy, Upendra Natha, Sri, Satyavathi, Karnatam, Dinakar, Neshaneni, Sathish Kumar   +5 more
core   +2 more sources

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source