Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang +11 more
wiley +1 more source
Integrating digital technologies in dental technician education: A comparative study of national examination in Asian countries. [PDF]
Hsu MS, Yeh CL, Cheng SJ, Lin CP.
europepmc +1 more source
Tioga, County of and Tioga County Unit 8850, CSEA, Local 1000, AFSCME, AFL-CIO, Tioga County Local 854 (2005) [PDF]
core +1 more source
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo +10 more
wiley +1 more source
Performance of ChatGPT-4, Gemini, and DeepSeek-V3 on answering the multiple choice questions from Taiwan national dental technician licensing examinations and their self-learning abilities over a three-week period. [PDF]
Huang CY, Lee YP, Sun A, Chiang CP.
europepmc +1 more source
Pilon fracture: a case report of a 45-year-old dental technician. [PDF]
Mafi P, Stanley J, Hindocha S, Mafi R.
europepmc +1 more source
Tompkins County and Tompkins County Unit, Blue Collar Unit, CSEA, Local 1000 AFSCME, AFL-CIO, Tompkins County Local 855 (2008) [PDF]
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Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Murray Inc. and International Union, United Automobile, Aerospace and Agricultural Implement Workers of America (UAW) Local 1621 (2002) [PDF]
core +1 more source
RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang +12 more
wiley +1 more source

