Results 221 to 230 of about 9,778 (294)

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

open access: yesAdvanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li   +14 more
wiley   +1 more source

Factors associated with adherence to post-exposure prophylaxis among dental professionals in Brazil. [PDF]

open access: yesBraz Oral Res
Silva GCBD   +4 more
europepmc   +1 more source

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

open access: yesAdvanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji   +9 more
wiley   +1 more source

Oral health educational interventions for pharmacists and pharmacy staff: A scoping review. [PDF]

open access: yesExplor Res Clin Soc Pharm
Man H   +7 more
europepmc   +1 more source

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

open access: yesAdvanced Science, EarlyView.
This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen   +3 more
wiley   +1 more source

Impact Assessment of an Antimicrobial Stewardship Program in a Japanese University Dental Hospital. [PDF]

open access: yesInt Dent J
Sawai NY   +9 more
europepmc   +1 more source

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

open access: yesAdvanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang   +10 more
wiley   +1 more source

Risks of accidents involving biological material in Primary Care: analysis of the state of São Paulo (2020-2024). [PDF]

open access: yesRev Bras Med Trab
Panebianco D   +5 more
europepmc   +1 more source

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