Results 121 to 130 of about 2,515,207 (339)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Sequelae of Dental Trauma in the Primary Dentition

, 2010
Dental traumatic injuries are very common and occur frequently in children at an early age. Epidemiological studies have shown a frequency of approximately 30% of primary dentition that is affected by trauma.
H. Jaklová
core  

A Trauma System for Ireland: Report of the Trauma Steering Group [PDF]

, 2018
Injury is a public health problem of enormous magnitude, whether measured by years of productive life lost, prolonged or permanent disability, or financial cost.
Trauma Steering Group
core  

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Tooth Loss and Survival Analysis after Traumatic Injuries in Primary Dentition

Balkan Journal of Dental Medicine, 2017
Background/Aim: The aim of the present study was to investigate the treatment options, survival rate of traumatized primary teeth and evaluate the factors influencing the outcome.
Galovic Jelena, Vukojevic Tatjana, Ivosevic Jelena Nikolic, Perin Mirjana, Vicko Kristina, Rihter Ivana Demko, Petrovic Bojan   +6 more
doaj   +1 more source

Shining the light on childhood trauma in Ohio

, 2006
Title from PDF cover (viewed on June 21, 2007).; "Sponsored by the Ohio Department of Mental Health and the Childhood Trauma Task Force in partnership with the Ohio Family and Children First Cabinet Council"--P. 2 of cover.; "November 2006"--P.
Ohio. Childhood Trauma Task Force.
core  

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Interpretation of the International Association of Dental Traumatology guidelines for the prevention of traumatic dental injuries(2024) [PDF]

Kouqiang yixue
In February 2024, the International Association of Dental Traumatology(IADT) and the Academy for Sports Dentistry(ASD) jointly released guidelines for the prevention of dental trauma.
GAO Hui, YU Dongsheng
doaj   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source