Results 11 to 20 of about 57,495 (112)

Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System

Pharmaceutics, 2022
Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies.
T. Crowe, W. Hsu
semanticscholar   +1 more source

COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges

Human Vaccines & Immunotherapeutics, 2022
Multiple vaccines have recently been developed, and almost all the countries are presently vaccinating their population to tackle the COVID-19 pandemic.
K. Dhama, Manish Dhawan, R. Tiwari, T. Emran, Saikat Mitra, A. Rabaan, S. Alhumaid, Z. A. Alawi, Abbas Al Mutair   +8 more
semanticscholar   +1 more source

Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity

Science Translational Medicine, 2022
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization strategies are needed that elicit protection at mucosal portals of pathogen entry.
B. Hartwell, M. Melo, Peng Xiao, Ashley A. Lemnios, Na Li, Jason Y. H. Chang, Jingyou Yu, M. Gebre, A. Chang, L. Maiorino, Crystal Carter, Tyson J. Moyer, Neil C. Dalvie, Sergio A. Rodriguez-Aponte, Kristen A. Rodrigues, Murillo Silva, Heikyung Suh, Josetta Adams, J. Fontenot, J. C. Love, D. Barouch, F. Villinger, R. Ruprecht, D. Irvine   +23 more
semanticscholar   +1 more source

Effect of Intranasal Dexmedetomidine or Midazolam for Premedication on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomy and Adenoidectomy

JAMA Network Open, 2022
Key Points Question Do preoperative sedatives such as midazolam and dexmedetomidine have a protective effect against perioperative respiratory adverse events (PRAEs) while achieving adequate sedative effect?
Fangming Shen, Qin Zhang, Yahui Xu, Xing-he Wang, Jiayi Xia, Chao Chen, He Liu, Yueying Zhang   +7 more
semanticscholar   +1 more source

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

Science Translational Medicine, 2021
Intranasal vaccination of hamsters and rhesus macaques with ChAdOx1 nCoV-19 reduces shedding of SARS-CoV-2 after challenge. Intranasal SARS-CoV-2 vaccination Protection conferred by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines ...
N. van Doremalen, Jyothi N. Purushotham, Jonathan E. Schulz, M. Holbrook, T. Bushmaker, A. Carmody, J. Port, C. Yinda, A. Okumura, G. Saturday, F. Amanat, F. Krammer, P. Hanley, Brian J. Smith, J. Lovaglio, S. Anzick, Kent D. Barbian, C. Martens, S. Gilbert, T. Lambe, V. Munster   +20 more
semanticscholar   +1 more source

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

Signal Transduction and Targeted Therapy, 2022
The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain or increase the immune responses owing to ...
H. Lei, Aqu Alu, Jingyun Yang, Wen-hui Ren, Cai He, Tianxia Lan, Xuemei He, Li Yang, Jiong Li, Zhenling Wang, Xiangrong Song, Wei Wang, G. Lu, Xiawei Wei   +13 more
semanticscholar   +1 more source

Non-Clinical Safety Evaluation of Intranasal Iota-Carrageenan

PLoS ONE, 2015
Carrageenan has been widely used as food additive for decades and therefore, an extended oral data set is available in the public domain. Less data are available for other routes of administration, especially intranasal administration.
A. Hebar, Christiane Koller, J. Seifert, M. Chabicovsky, A. Bodenteich, A. Bernkop‐Schnürch, Andreas Grassauer, E. Prieschl-Grassauer   +7 more
semanticscholar   +1 more source

Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action

Pharmaceutics, 2022
Acute and chronic administration of intranasal oxytocin and vasopressin have been extensively utilized in both animal models and human preclinical and clinical studies over the last few decades to modulate various aspects of social cognition and their ...
S. Yao, K. Kendrick
semanticscholar   +1 more source

Cardiovascular complications related to cocaine use: case report [PDF]

, 2006
BACKGROUND AND OBJECTIVES: Cocaine is the most commonly used illicit drug and its acute and chronic effects are related to a variety of physiological changes, mainly in the cardiovascular system.
Gazoni, Fernanda Martins, Guimarães, Hélio Penna, Kawamura, Carolina, Lopes, Antonio Carlos, Lopes, Renato Delascio, Sandre, Letícia Vendrame, Truffa, Adriano A. M.   +6 more
core   +2 more sources

Tratamiento quirúrgico de un caso raro de diente ectópico en la pared lateral de la cavidad nasal [PDF]

, 2020
Entre as formas de abordagem dos casos de dentes ectópicos, o tratamento cirúrgico é uma opção válida e deve ser considerada,uma vez que é simples e permite a visualização direta e uma rápida recuperação. O objetivo deste artigo é relatar um caso raro de
Amália Moreno, Ana Karina de Medeiros Tormes, Ana Paula Veras Sobral, Emanuel Dias Oliveira e Silva, José Alcides Almeida de Arruda, Manoela Mourade Bortoli, Ricardo José Holanda Vasconcellos   +6 more
core   +1 more source