Results 11 to 20 of about 64,673 (113)

Intranasal COVID-19 vaccines: From bench to bed

EBioMedicine, 2022
Summary Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization. However, vaccination today failed to prevent the virus infection through the upper respiratory tract, which is partially due to the absence of mucosal ...
Aqu Alu, Li Chen, H. Lei, Yuquan Wei, Xiaohe Tian, Xiawei Wei   +5 more
semanticscholar   +1 more source

Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System

Pharmaceutics, 2022
Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies.
T. Crowe, W. Hsu
semanticscholar   +1 more source

Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity

Science Translational Medicine, 2022
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization strategies are needed that elicit protection at mucosal portals of pathogen entry.
B. Hartwell, M. Melo, Peng Xiao, Ashley A. Lemnios, Na Li, Jason Y. H. Chang, Jingyou Yu, M. Gebre, A. Chang, L. Maiorino, Crystal Carter, Tyson J. Moyer, Neil C. Dalvie, Sergio A. Rodriguez-Aponte, Kristen A. Rodrigues, Murillo Silva, Heikyung Suh, Josetta Adams, J. Fontenot, J. C. Love, D. Barouch, F. Villinger, R. Ruprecht, D. Irvine   +23 more
semanticscholar   +1 more source

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

Epilepsy & Behavior Reports, 2022
Nasal administration of treatments for neurologic conditions, including rescue therapies to treat seizure clusters among people with epilepsy, represents a meaningful advance in patient care.
Steve S. Chung, J. Peters, K. Detyniecki, W. Tatum, A. Rabinowicz, E. Carrazana   +5 more
semanticscholar   +1 more source

COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges

Human Vaccines & Immunotherapeutics, 2022
Multiple vaccines have recently been developed, and almost all the countries are presently vaccinating their population to tackle the COVID-19 pandemic.
K. Dhama, Manish Dhawan, R. Tiwari, T. Emran, Saikat Mitra, A. Rabaan, S. Alhumaid, Z. A. Alawi, Abbas Al Mutair   +8 more
semanticscholar   +1 more source

Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies

Acta Pharmaceutica Sinica B, 2021
The management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the use of
C. Costa, J. Moreira, J. S. Sousa Lobo, A. C. Silva   +3 more
semanticscholar   +1 more source

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

Science Translational Medicine, 2021
Intranasal vaccination of hamsters and rhesus macaques with ChAdOx1 nCoV-19 reduces shedding of SARS-CoV-2 after challenge. Intranasal SARS-CoV-2 vaccination Protection conferred by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines ...
Neeltje van Doremalen, Jyothi N. Purushotham, Jonathan E. Schulz, M. Holbrook, T. Bushmaker, A. Carmody, J. Port, C. Yinda, A. Okumura, G. Saturday, F. Amanat, F. Krammer, P. Hanley, Brian J. Smith, J. Lovaglio, S. Anzick, Kent D. Barbian, C. Martens, S. Gilbert, T. Lambe, V. Munster   +20 more
semanticscholar   +1 more source

Non-Clinical Safety Evaluation of Intranasal Iota-Carrageenan

PLoS ONE, 2015
Carrageenan has been widely used as food additive for decades and therefore, an extended oral data set is available in the public domain. Less data are available for other routes of administration, especially intranasal administration.
A. Hebar, Christiane Koller, J. Seifert, M. Chabicovsky, A. Bodenteich, A. Bernkop‐Schnürch, Andreas Grassauer, E. Prieschl-Grassauer   +7 more
semanticscholar   +1 more source

Cardiovascular complications related to cocaine use: case report [PDF]

, 2006
BACKGROUND AND OBJECTIVES: Cocaine is the most commonly used illicit drug and its acute and chronic effects are related to a variety of physiological changes, mainly in the cardiovascular system.
Gazoni, Fernanda Martins, Guimarães, Hélio Penna, Kawamura, Carolina, Lopes, Antonio Carlos, Lopes, Renato Delascio, Sandre, Letícia Vendrame, Truffa, Adriano A. M.   +6 more
core   +2 more sources

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

Cell, 2020
The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a prefusion stabilized spike protein (ChAd-SARS-CoV-2-S)
Ahmed O. Hassan, Natasha M. Kafai, I. Dmitriev, J. Fox, Brittany K. Smith, Ian B Harvey, Rita E. Chen, Emma S. Winkler, Alex W. Wessel, J. Case, E. Kashentseva, B. McCune, Adam Leitman Bailey, Haiyan Zhao, L. VanBlargan, Ya-Nan Dai, Meisheng Ma, L. Adams, S. Shrihari, Jonathan E. Danis, Lisa E. Gralinski, Yixuan J. Hou, A. Schäfer, A. S. Kim, Shamus P. Keeler, D. Weiskopf, R. Baric, M. Holtzman, D. Fremont, D. Curiel, M. Diamond   +30 more
semanticscholar   +1 more source