Results 11 to 20 of about 56,940 (111)
Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery
Pharmaceutics, 2023 Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong +2 more
semanticscholar +1 more source
Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
bioRxiv, 2023 Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission.
Gabriela Baldeon Vaca +19 more
semanticscholar +1 more source
Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery
Pharmaceutics, 2023 Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases.
Rebecca Maher +5 more
semanticscholar +1 more source
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
Science, 2022 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission.
Tianyang Mao +10 more
semanticscholar +1 more source
Intranasal drug delivery: opportunities and toxicologic challenges during drug development
Drug Delivery and Translational Research, 2021 Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS indications.
Lea-Adriana Keller +2 more
semanticscholar +1 more source
Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System
Pharmaceutics, 2022 Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies.
T. Crowe, W. Hsu
semanticscholar +1 more source
COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges
Human Vaccines & Immunotherapeutics, 2022 Multiple vaccines have recently been developed, and almost all the countries are presently vaccinating their population to tackle the COVID-19 pandemic.
K. Dhama +8 more
semanticscholar +1 more source
Science Translational Medicine, 2022 To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization strategies are needed that elicit protection at mucosal portals of pathogen entry.
B. Hartwell +23 more
semanticscholar +1 more source
JAMA Network Open, 2022 Key Points Question Do preoperative sedatives such as midazolam and dexmedetomidine have a protective effect against perioperative respiratory adverse events (PRAEs) while achieving adequate sedative effect?
Fangming Shen +7 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2022 The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain or increase the immune responses owing to ...
H. Lei +13 more
semanticscholar +1 more source