Results 31 to 40 of about 56,940 (111)

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

Vaccines, 2021
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
R. King, A. Silva-Sánchez, Jessica N. Peel, David Botta, A. Dickson, Amelia K. Pinto, S. Meza-Perez, S. Allie, Michael D. Schultz, Mingyong Liu, J. Bradley, S. Qiu, Guang Yang, Fen Zhou, Esther Zumaquero, Thomas S. Simpler, B. Mousseau, J. Killian, B. Dean, Q. Shang, J. Tipper, Christopher A Risley, K. Harrod, Tsungwei Feng, Y. Lee, B. Shiberu, Vyjayanthi Krishnan, I. Peguillet, Jianfeng Zhang, T. Green, T. Randall, J. Suschak, B. Georges, J. Brien, F. Lund, M. Roberts   +35 more
semanticscholar   +1 more source

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

bioRxiv, 2021
The deployment of a vaccine that limits transmission and disease likely will be required to end the Coronavirus Disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally-administered chimpanzee adenovirus-vectored
Ahmed O. Hassan, F. Feldmann, Haiyan Zhao, D. Curiel, A. Okumura, Tsing-Lee Tang-Huau, J. Case, Kimberly Meade-White, Julie A. Callison, J. Lovaglio, P. Hanley, D. Scott, D. Fremont, H. Feldmann, M. Diamond   +14 more
semanticscholar   +1 more source

Inhaled and intranasal ciclesonide for the treatment of covid-19 in adult outpatients: CONTAIN phase II randomised controlled trial

British medical journal, 2021
Objective To determine if inhaled and intranasal ciclesonide are superior to placebo at decreasing respiratory symptoms in adult outpatients with covid-19. Design Randomised, double blind, placebo controlled trial.
N. Ezer, S. Belga, N. Daneman, Adrienne Chan, Benjamin M. Smith, Shay-Anne Daniels, Kristen Moran, Charlotte Besson, Lulu Smyth, S. Bartlett, A. Benedetti, James G. Martin, T. Lee, E. McDonald   +13 more
semanticscholar   +1 more source

Asthmatics as a susceptible population in health risk assessment of airborne chemicals [PDF]

, 2016
Asthma is a common chronic airway disease and about 235-300 million individuals of all ages are affected by the disease around the world. A precondition of asthma has been suggested to increase individual susceptibility to acute exposure from airborne ...
Johansson, Mia
core   +1 more source

Vacinas anticárie [PDF]

, 2013
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasA cárie dentária é uma das doenças infecciosas mais comum no homem.
Santos, Joana Gouveia dos
core   +3 more sources

Intranasal insulin

Journal of neuroendocrinology, 2021
The intranasal (IN) route enables the delivery of insulin to the central nervous system in the relative absence of systemic uptake and related peripheral side effects.
M. Hallschmid
semanticscholar   +1 more source

Breath biomarkers in idiopathic pulmonary fibrosis:A systematic review 11 Medical and Health Sciences [PDF]

, 2019
Background: Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomarkers discriminate between patients
A Mashir, A Sandrini, A Sundarakrishnan, A Ulanowska, AG Fois, AG Paulovich, AM Peel, AM Tager, American Thoracic S, European Respiratory S, American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias, AU Wells, AU Wells, AU Wells, AU Wells, B Ley, B Ley, BC Wallace, BW Kinder, C Agostini, D Makris, D Moher, E Bargagli, E Bargagli, E Fireman, E Ono, FJ Martinez, FJ Martinez, G Bagnato, G Jenkins, G Raghu, G Raghu, G Raghu, H Ishii, H Lehtonen, H Satoh, HL Petsky, HR Collard, I Ojanguren, IO Rosas, J Guiot, J Hutchinson, J Schildge, J Zhou, JA Bjoraker, JC Rufo, JP Hutchinson, K Hildebrand, K Psathakis, K Toren, KP Tiev, KP Tiev, KR Flaherty, L Guilleminault, L Lehtimaki, LD Bos, M Corradi, M Hogman, MP Schee van der, N Alkhouri, NM Tsoukias, NP Barlo, P Cameli, P Cameli, P Condorelli, P Montuschi, P Paredi, PF Whiting, PI Latsi, PJ Mazzone, R Antonelli Incalzi, R Hubbard, R Hubbard, RA Dweik, RE Girgis, RG Jenkins, RM Bois du, RM Effros, S Chow, S Kanoh, S Scarlata, S Scarlata, SA Kharitonov, SC George, SL Walsh, T Greulich, T Okamoto, TE King Jr, TIPFCR Network, TM Maher, TM Oliveira de, U Kalluri, V Cottin, V Rihak, Y Jegal, Y Shimizu, Y Teng, Y Yamada, Y Zhao, YC Hou, YC Hsu   +99 more
core   +1 more source

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial.

JAMA Neurology, 2020
Importance Insulin modulates aspects of brain function relevant to Alzheimer disease and can be delivered to the brain using intranasal devices. To date, the use of intranasal insulin to treat persons with mild cognitive impairment and Alzheimer's ...
S. Craft, R. Raman, T. Chow, M. Rafii, Chung‐Kai Sun, R. Rissman, M. Donohue, J. Brewer, C. Jenkins, K. Harless, D. Gessert, P. Aisen   +11 more
semanticscholar   +1 more source

Intranasal delivery of mitochondria for treatment of Parkinson’s Disease model rats lesioned with 6-hydroxydopamine

Scientific Reports, 2021
The feasibility of delivering mitochondria intranasally so as to bypass the blood–brain barrier in treating Parkinson's disease (PD), was evaluated in unilaterally 6-OHDA-lesioned rats. Intranasal infusion of allogeneic mitochondria conjugated with Pep-1
Juichih Chang, Yi-Chun Chao, Huei-Shin Chang, Yu-Ling Wu, Hui-Ju Chang, Yongshiou Lin, W. Cheng, Ta-Tsung Lin, Chin‐San Liu   +8 more
semanticscholar   +1 more source

Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery

Pharmaceutics, 2021
This study aimed at delivering intranasal zolmitriptan directly to the brain through preparation of bilosomes incorporated into a mucoadhesive in situ gel with extended nasal mucociliary transit time.
M. M. El Taweel, M. H. Aboul-Einien, M. Kassem, Nermeen A. Elkasabgy   +3 more
semanticscholar   +1 more source