Results 31 to 40 of about 57,495 (112)

Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice

bioRxiv, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can cause neurological disease in humans, but little is known about the pathogenesis of SARS-CoV-2 infection in the central nervous system.
P. Kumari, H. Rothan, Janhavi Natekar, S. Stone, H. Pathak, Philip G. Strate, K. Arora, M. Brinton, Mukesh Kumar   +8 more
semanticscholar   +1 more source

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

Vaccines, 2021
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
R. King, A. Silva-Sánchez, Jessica N. Peel, David Botta, A. Dickson, Amelia K. Pinto, S. Meza-Perez, S. Allie, Michael D. Schultz, Mingyong Liu, J. Bradley, S. Qiu, Guang Yang, Fen Zhou, Esther Zumaquero, Thomas S. Simpler, B. Mousseau, J. Killian, B. Dean, Q. Shang, J. Tipper, Christopher A Risley, K. Harrod, Tsungwei Feng, Y. Lee, B. Shiberu, Vyjayanthi Krishnan, I. Peguillet, Jianfeng Zhang, T. Green, T. Randall, J. Suschak, B. Georges, J. Brien, F. Lund, M. Roberts   +35 more
semanticscholar   +1 more source

Inhaled and intranasal ciclesonide for the treatment of covid-19 in adult outpatients: CONTAIN phase II randomised controlled trial

British medical journal, 2021
Objective To determine if inhaled and intranasal ciclesonide are superior to placebo at decreasing respiratory symptoms in adult outpatients with covid-19. Design Randomised, double blind, placebo controlled trial.
N. Ezer, S. Belga, N. Daneman, Adrienne Chan, Benjamin M. Smith, Shay-Anne Daniels, Kristen Moran, Charlotte Besson, Lulu Smyth, S. Bartlett, A. Benedetti, James G. Martin, T. Lee, E. McDonald   +13 more
semanticscholar   +1 more source

Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma [PDF]

, 2011
Asthma patients who continue to experience symptoms despite being on regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) or anti-leukotrienes (LTRA) are two treatment options that could be considered ...
Adams, Adinoff, Altman, Anonymous, Anonymous, Anonymous, Baraniuk, Barnes, Bateman, Bateman, Becker, Bergmann, Bjermer, Bjermer, Bjermer, Bleecker, Borker, Boulet, Bousquet, Brabson, Buchvald, Buchvald, Buhl, Busse, Caffey, Calhoun, Calhoun, Cash, Cates, Ceylan, Chopra, Chuchalin, Covar, Currie, Currie, Currie, Davies, Davis, Deeks, Dekhuijzen, Delaronde, Dempsey, Deykin, Dicpinigaitis, Donohue, Dorinsky, Dorinsky, Dorinsky, Dorinsky, Ducharme, Ducharme, Ducharme, Ducharme, Dunn, Edelman, Edin, Egger, Eliraz, Eliraz, Ernst, Everden, Fish, Fish, Gabrijelcic, Georgitis, Giannini, Gold, Gold, Green, Green, Green, Grosclaude, Grzelewska-Rzymowska, Gupta, Havlucu, Hendeles, Higgins, Higgins, Horwitz, Houghton, Ilowite, Inoue, Jarvis, Jarvis, Jenkins, Johnson, Jonsson, Kalberg, Kalberg, Kanniess, Kanniess, Karaman, Kardos, Keith, Kemp, Keonig, Kerwin, Knobil, Knorr, Koenig, Kohrogi, Krawiec, Larsen, Laviolette, Lazarus, Lee, Lee, Lee, Lee, Leflein, Leibman, Leibman, Lemanske, Lipworth, Lipworth, Liu, Lotvall, Lougheed, Maspero, Maspero, Maspero, McCarthy, McCarthy, Meltzer, Miraglia del Giudice, Mitchell, Molitor, Naedele-Risha, Nathan, Nathan, Nathan, Nathan, Nathan, Nelson, Nelson, Nelson, Nelson, Nelson, Ni Chroinin, Ni Chroinin, Nsouli, O'Connor, O'Sullivan, Ohbayashi, Ohbayashi, Ollendorf, Oppenheimer, Orgega-Cisneros, Paterson, Pavord, Pearlman, Perera, Perez, Peroni, Peroni, Petermann, Peters, Pieters, Pieters, Plaza, Polos, Powell, Price, Ram, Reddel, Rees, Riccioni, Rickard, Rickard, Ringdal, Ringdal, Rosenhall, Salpeter, Serrier, Sheth, Sims, Sims, Sims, Smith, Sorkness, Stanford, Stelmach, Stelmach, Stelmach, Stelmach, Stelmach, Stelmach, Stempel, Stempel, Stevenson, Storms, Storms, Terzano, Thien, Tolley, Vaquerizo, Volovitz, Walters, Warner, Wasserman, Wenzel, Wilson, Wilson, Wilson, Wytrychowski, Yurdakul, Zarkovic, Zimmerman   +207 more
core   +1 more source

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

bioRxiv, 2021
The deployment of a vaccine that limits transmission and disease likely will be required to end the Coronavirus Disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally-administered chimpanzee adenovirus-vectored
Ahmed O. Hassan, F. Feldmann, Haiyan Zhao, D. Curiel, A. Okumura, Tsing-Lee Tang-Huau, J. Case, Kimberly Meade-White, Julie A. Callison, J. Lovaglio, P. Hanley, D. Scott, D. Fremont, H. Feldmann, M. Diamond   +14 more
semanticscholar   +1 more source

Transnasal Removal of Ectopic Supernumerary Tooth from Cleft Patient [PDF]

, 2015
Background: The ectopic teeth can be permanent, deciduous or supernumerary and they are changes caused by the morphogenesis and growth of tissue outside their common positions. The ectopic inclusions occur in about 1% of the population.
Pita Neto, Ivo Cavalcante, Franco, Jeférson Martins Pereira Lucena, Bringel, Romildo José de Siqueira, Santana, Milana Drumond Ramos, Batista, Hermes Melo Teixeira, Pita, Pablo, Soares, Eduardo Costa Studart, de Abreu, Luiz Carlos, Rodrigues, Luciano Miller Reis   +8 more
core   +2 more sources

Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

International Journal of Nanomedicine
Addressing disorders related to the central nervous system (CNS) remains a complex challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry of external substances into the brain tissue.
Jain Koo, Chaemin Lim, Kyung Taek Oh
semanticscholar   +1 more source

Marijuana: Current Concepts† [PDF]

, 2013
Marijuana (cannabis) remains a controversial drug in the twenty-first century. This paper considers current research on use of Cannabis sativa and its constituents such as the cannabinoids.
Donald E. Greydanus, Elizabeth K. Hawver, Joav Merrick, Megan M. Greydanus   +3 more
core   +3 more sources

Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

Stem Cells Translational Medicine, 2020
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression.
M. Losurdo, M. Pedrazzoli, C. D'Agostino, C. Elia, F. Massenzio, E. Lonati, Mario Mauri, L. Rizzi, L. Molteni, E. Bresciani, E. Dander, G. D'Amico, A. Bulbarelli, A. Torsello, M. Matteoli, M. Buffelli, S. Coco   +16 more
semanticscholar   +1 more source

Ozone Inhalation Attenuated the Effects of Budesonide on Aspergillus fumigatus-Induced Airway Inflammation and Hyperreactivity in Mice. [PDF]

, 2019
Inhaled glucocorticoids form the mainstay of asthma treatment because of their anti-inflammatory effects in the lung. Exposure to the air pollutant ozone (O3) exacerbates chronic airways disease.
Flayer, Cameron H, Ge, Moyar Q, Haczku, Angela, Hwang, Jin W, Jiang, Zhilong, Kokalari, Blerina, Redai, Imre G   +6 more
core