Results 41 to 50 of about 64,673 (113)

Inhaled and intranasal ciclesonide for the treatment of covid-19 in adult outpatients: CONTAIN phase II randomised controlled trial

open access: yesBritish medical journal, 2021
Objective To determine if inhaled and intranasal ciclesonide are superior to placebo at decreasing respiratory symptoms in adult outpatients with covid-19. Design Randomised, double blind, placebo controlled trial.
N. Ezer   +13 more
semanticscholar   +1 more source

The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation [PDF]

open access: yes, 2002
Background: This review examines the clinical effectiveness and cost-effectiveness of hand-held inhalers to deliver medication for the routine management of chronic asthma in children aged between 5 and 15 years.
Beverley, C.   +4 more
core   +1 more source

Ozone Inhalation Attenuated the Effects of Budesonide on Aspergillus fumigatus-Induced Airway Inflammation and Hyperreactivity in Mice. [PDF]

open access: yes, 2019
Inhaled glucocorticoids form the mainstay of asthma treatment because of their anti-inflammatory effects in the lung. Exposure to the air pollutant ozone (O3) exacerbates chronic airways disease.
Flayer, Cameron H   +6 more
core  

Evaluation of intranasal delivery route of drug administration for brain targeting.

open access: yesBrain Research Bulletin, 2018
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side ...
F. Erdő   +4 more
semanticscholar   +1 more source

Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

open access: yesStem Cells Translational Medicine, 2020
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression.
M. Losurdo   +16 more
semanticscholar   +1 more source

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

open access: yesMolecular Psychiatry, 2020
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and behavior have steadily increased over the last two decades, stimulating considerable interest in its psychiatric application.
D. Quintana   +5 more
semanticscholar   +1 more source

Intranasal insulin

open access: yesJournal of neuroendocrinology, 2021
The intranasal (IN) route enables the delivery of insulin to the central nervous system in the relative absence of systemic uptake and related peripheral side effects.
M. Hallschmid
semanticscholar   +1 more source

Farmacología de los opioides [PDF]

open access: yes, 2005
En los últimos años se ha avanzado en el conocimiento de la farmacología de los opioides. Los opioides endógenos y exógenos se unen a receptores específicos. Existen cuatro tipos de receptores opioides; mu, kappa, delta y nociceptina.
Alvarez García, Yolanda, Farre, Magi
core   +1 more source

Organ-specific allergen challenges in airway allergy: Current utilities and future directions [PDF]

open access: yes, 2023
Atopy has been long used as the screening method for airway allergy. Nevertheless, aeroallergens can trigger respiratory symptoms not only in atopic patients (atopic res piratory allergy, ARA), but also in non-atopic subjects (local respiratory allergy ...
Alba-Linero, Carmen   +8 more
core   +1 more source

Etiopatogenia de la osteonecrosis idiopática de cadera: situación actual [PDF]

open access: yes, 2009
Al margen de las numerosas hipótesis etiopatogénicas sobre la osteonecrosis atraumática de cadera, la fisiopatología de la enfermedad sigue siendo, en la actualidad, motivo de debate.
Escribá, I.   +2 more
core  

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