Results 61 to 70 of about 4,274 (211)

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

FAM20C Functions Intracellularly Within Both Ameloblasts and Odontoblasts In Vivo [PDF]

, 2013
FAM20C, also known as Golgi casein kinase (G‐CK), is proposed to be the archetype for a family of secreted kinases that phosphorylate target proteins in the Golgi and in extracellular matrices, but FAM20C serving an extracellular function is ...
Al-Hashimi, Brunati, Chan, Delgado, Duncan, Feng, Fincham, Ishikawa, Kawasaki, Nadanaka, Nalbant, O'Sullivan, Ryu, Simmer, Simpson, Tagliabracci, Tagliabracci, Wang, Wang, Yamakoshi   +19 more
core   +1 more source

Interradicular dentin dysplasia associated with amelogenesis imperfecta with taurodontism or trichodentoosseous syndrome: A diagnostic dilemma

Indian Journal of Dental Research, 2014
Amelogenesis imperfecta is a hereditary disorder with diverse clinical presentation, where enamel is the tissue that is primarily affected either quantitatively or qualitatively.
Veda Hegde, K Srikanth
doaj   +1 more source

Dentinogenesis Imperfecta : A Family which was Affected for Over Three Generations [PDF]

Journal of Clinical and Diagnostic Research, 2013
Dentinogenesis Imperfecta (DI) or hereditary opalescent dentin is inherited in a simple autosomal dominant mode with high penetrance and low mutation rates. It generally affects both the deciduous and the permanent dentitions.
Poornima Surendra, Rohan Shah, Roshan N.M., V.V. Subba Reddy   +3 more
doaj   +1 more source

Evaluation of dental manifestations in X-linked hypophosphatemia using orthopantomography.

PLoS ONE
BackgroundX-linked hypophosphatemia (XLH) is the most common inherited form of rickets. The presence of sequence variations in the phosphate regulating endopeptidase homolog X-linked (PHEX) gene is associated with increased production of fibroblast ...
Rena Okawa, Misato Takagi, Takashi Nakamoto, Naoya Kakimoto, Kazuhiko Nakano   +4 more
doaj   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, Volume 255, Issue 3, Page 228-245, March 2026.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries

Frontiers in Dental Medicine, 2022
Dental caries is the most common chronic disease in children and adults worldwide. The complex etiology of dental caries includes environmental factors as well as host genetics, which together contribute to inter-individual variation in susceptibility ...
Mairobys Socorro, Priyanka Hoskere, Catherine Roberts, Lyudmila Lukashova, Kostas Verdelis, Kostas Verdelis, Kostas Verdelis, Elia Beniash, Elia Beniash, Dobrawa Napierala, Dobrawa Napierala   +10 more
doaj   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 107-127, March 2026.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I [PDF]

, 2017
Umbilical cord blood (UCB) is a promising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approaches for several genetic diseases that can be diagnosed at birth.
A Oikawa, A Pievani, A Pievani, A Scaradavou, AE Willing, B Sacchetti, C Davenport, C Schulte, CM Simonaro, DC Mendez, DE Harrison, DE Harrison, DJ Rowan, DK Kim, DL Selle, DT Harris, F Gatto, F Kubaski, F Migishima, FL Wilkinson, HE Broxmeyer, J Palis, JJ Boelens, K Ohmi, K Uchida, K Uchida, KK Ballen, L Lu, LA Clarke, LA Clarke, M Aldenhoven, M Aldenhoven, M Aldenhoven, M Aldenhoven, M Beck, M Schmidt, ME Bernardo, MF Garcia-Rivera, O Levy, S Coşkun, S Garbuzova-Davis, S Jayaraman, S Tomatsu, S Tomatsu, S Tomatsu, SC Kuehn, SH Boyer, SJ Morrison, SL Staba, VK Prasad, VK Prasad, W Chuan, XY Zhong, Y Zheng, ZY Li   +54 more
core   +2 more sources

DREAMER: Rapid and Simultaneous Multiple Contrast Magnetic Resonance Imaging of Solid and Soft Tissue

Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1513-1527, March 2026.
ABSTRACT Purpose Pediatric craniofacial imaging may involve examination of both the skull and brain tissues via CT and MRI, respectively. DREAMER (Dual Repetition and Echo Acquisition with Multi‐contrast Encoding and Reconstruction) simultaneously acquires solid‐ and soft‐tissue images, potentially providing a rapid, high‐resolution, and radiation‐free
Brian‐Tinh Duc Vu, Nada Kamona, Felix W. Wehrli, Rajiv S. Deshpande, Hee Kwon Song, Allison Hu, Emily Baccaglini, Scott P. Bartlett, Chamith S. Rajapakse   +8 more
wiley   +1 more source