Results 51 to 60 of about 584,020 (297)

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

Advanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy, Jesus Nieves, Lukas Königer, Matthias Peindl, Fabio Erhard, Marc Möllmann, Anke Klingner, Markus Münig, Bibin Babu, Thomas Schwarz, Marco Metzger, Gudrun Dandekar, Maximiliane Wußmann, Jan Hansmann   +13 more
wiley   +1 more source

Streptococcus mutans biofilm formation and cell viability on polymer-infiltrated ceramic and yttria-stabilized polycrystalline zirconium dioxide ceramic

, 2019
Objective: The aim of this study was to investigate the biofilm formation and cell viability of a polymer-infiltrated ceramic (PIC) and an yttria-stabilized polycrystalline zirconium dioxide ceramic (Y-TZP). The null hypothesis was that there would be no
Pereira, S. M.B. [UNESP], Amaral, M., Carvalho, A. B.G. [UNESP], Bottino, M. A. [UNESP], Pereira, C. A. [UNESP], Melo, R. M. [UNESP], Camargo, S. E.A., Milhan, N. V.M. [UNESP]   +7 more
core   +1 more source

Biomechanical, operative and biological aspects of the cervical margin relocation: a case report

, 2022
The clinical success of tooth-colored indirect restorations has been confirmed in several studies. However, inlays and onlays restorations in Class II cavities with deep gingival margins can still be considered a clinical challenge.
Grassi, Elisa Donaria Aboucauch [UNESP], Ingrid Fernandes Mathias-Santamaria, Mathias-Santamaria, Ingrid Fernandes, Guilherme Schmitt de Andrade, Prado, Taiana Paola [UNESP], Elisa Donaria Aboucauch Grassi, Paula Bernardon, Eliseo Pablo Chun, Taiana Paola Prado, Santamaria, Mauro Pedrine [UNESP], Mauro Pedrine Santamaria, Bernardon, Paula, Chun, Eliseo Pablo, Saavedra, Guilherme De Siqueira Ferreira Anzaloni [UNESP], Augusto, Marina Gullo, Marina Gullo Augusto, Guilherme de Siqueira Ferreira Anzaloni Saavedra, De Andrade, Guilherme Schmitt   +17 more
core   +1 more source

Advanced Flexible Robotic Systems for the Early Diagnosis and Treatment of Cancer and Cardiovascular Diseases

Advanced Robotics Research, EarlyView.
Flexible surgical robots are advancing minimally invasive interventions for cardiovascular diseases and cancer by enabling precise navigation through complex, submillimeter anatomical pathways. This review highlights recent innovations in actuation, bio‐integrated sensing, AI‐assisted control, and friction‐reduction technologies, discusses current ...
Hermione Truong, Chi Cong Nguyen, Hannah Thuy Truong, Kefan Zhu, Adrienne Ji, James Davies, Emanuele Nicotra, Bibhu Sharma, Jingjing Wan, Patrick Pruscino, Shing Wai Wong, Hoang‐Phuong Phan, Phuoc Thien Phan, Nigel H. Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

The Evidence-practice Gap in Minimal Intervention Dentistry: An International Comparison Between Dentists in Japan and Brazil

Objectives: This study was designed to: 1) evaluate and compare the evidence-practice gap (EPG) in minimal intervention dentistry (MID) in Japan and Brazil by measuring concordance between dentists' clinical practice and published evidence; and 2 ...
Sumida, Futoshi, Yokoyama, Yoko, Kakudate, Naoki, Matsumoto, Yuki, Da Silva Tagliaferro, Elaine Pereira [UNESP], Gordan, Valeria V., Gilbert, Gregg H.   +6 more
core   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

The color stability of artificial white spot lesions treated with resin infiltration after exposure to staining beverages

BMC Oral Health
Background To evaluate the effect of staining beverages on the color-changing of resin-infiltrated artificial white spot lesions (WSLs). Methods Thirty-five artificial WSLs were created by pH cycling on flat bovine teeth specimens.
Apinya Limvisitsakul, Anisha Komalsingsakul, Pongsakorn Thamsrithip, Yod Thammasupapong, Supada Chaisomsukrudee, Sorawit Aramlerttrakul, Pisol Senawongse   +6 more
doaj   +1 more source

Effect of calcium and fluoride addition to hydrogen peroxide bleaching gel on tooth diffusion, color, and microhardness

, 2019
Objectives: The aim of this study was to evaluate the effect of calcium and fluoride addition to a 35% hydrogen peroxide (HP) bleaching gel with regard to its diffusion through the tooth structure, enamel microhardness, and bleaching efficacy.
Borges, Alessandra B. [UNESP], Torres, Carlos R.G. [UNESP], Silva, Tatiane Josefa [UNESP], Zanatta, Rayssa Ferreira [UNESP]   +3 more
core   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source