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Dengue virus surveillance: the co-circulation of DENV-1, DENV-2 and DENV-3 in the State of Rio de Janeiro, Brazil.

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2004
This study presents the results obtained in the monitoring of dengue virus (DENV) transmission in the Greater Metropolitan Region of the State of Rio de Janeiro, in the period 2000-2001. A total of 5324 serum samples from suspected cases of dengue were analysed in order to confirm dengue infection.
T. S. De Simone   +8 more
semanticscholar   +4 more sources

Severe dengue due to secondary DENV-1 infection in Mainland China.

Journal of Clinical Virology, 2013
Wen-xin Hong   +13 more
semanticscholar   +3 more sources

A Phase 1, Open Label- Assessment of a Dengue Virus-1 Live Virus Human Challenge - (DENV-1-LVHC) Strain.

Journal of Infectious Diseases, 2020
BACKGROUND Dengue human infection models (DHIM) have been used as a safe means to test the viability of prophylaxis and therapeutics. METHODS A phase I study of 12 healthy adult volunteers using a challenge virus, DENV-1-LVHC, strain 45AZ5, was ...
T. Endy   +17 more
semanticscholar   +1 more source

Genetic diversity and spatiotemporal dynamics of DENV-1 and DENV-2 infections during the 2012–2013 outbreak in Mexico

Virology, 2022
Dengue fever is caused by four related dengue virus serotypes, DENV-1 to DENV-4, where each serotype comprises distinct genotypes and lineages. The last major outbreak in Mexico occurred during 2012 and 2013, when 112,698 confirmed cases were reported (DENV-1 and DENV-2 were predominant).
Eduardo D. Rodríguez-Aguilar   +5 more
openaire   +2 more sources

Serotype and genomic diversity of dengue virus during the 2023 outbreak in Pakistan reveals the circulation of genotype III of DENV‐1 and cosmopolitan genotype of DENV‐2

Journal of Medical Virology
Dengue, a mosquito‐borne viral disease, poses a significant public health challenge in Pakistan, with a significant outbreak in 2023, prompting our investigation into the serotype and genomic diversity of the dengue virus (DENV).
Z. Jamal   +9 more
semanticscholar   +1 more source

Genotypic variability analysis of DENV-1 in Mexico reveals the presence of a novel Mexican lineage

Archives of Virology, 2018
Here, we report for the first time the circulation of dengue virus type 1 (DENV-1) belonging to the lineage IV of genotype V (African American genotype) based on phylogenetic analysis of nucleotide sequences from 10 DENV-1-positive samples obtained in Mexico between 2012 and 2014. Our data revealed that the lineages III and IV of DENV-1 genotype V were
Everardo Curiel-Quesada   +14 more
openaire   +3 more sources

Generation and preclinical evaluation of a DENV-1/2 prM+E chimeric live attenuated vaccine candidate with enhanced prM cleavage

Vaccine, 2013
In the absence of a vaccine or sustainable vector control measures, illnesses caused by dengue virus infection remain an important public health problem in many tropical countries. During the export of dengue virus particles, furin-mediated cleavage of the prM envelope protein is usually incomplete, thus generating a mixture of immature, partially ...
Poonsook Keelapang   +9 more
openaire   +3 more sources

Dengue and severe dengue.

Clinical Microbiology Reviews
SUMMARYDengue is an acute mosquito-borne viral disease that is highly prevalent throughout the tropical world. The geographic footprint of the four dengue viruses (DENV-1 to -4) that cause this disease and their Aedes mosquito vector is expanding ...
S. Kalimuddin   +3 more
semanticscholar   +1 more source

Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

Antiviral Research, 2013
Moon Y. F. Tay   +7 more
semanticscholar   +1 more source

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