Aged AG129 mice support the generation of highly virulent novel mouse-adapted DENV (1-4) viruses exhibiting neuropathogenesis and high lethality. [PDF]
Virus ResDengue virus infection in humans ranges from asymptomatic infection to severe infection, with ∼2.5 % overall disease fatality rate. Evidence of neurological manifestations is seen in the severe form of the disease, which might be due to the direct invasion of the viruses into the CNS system but is poorly understood.
Siddqui G +13 more
europepmc +5 more sources
Retrospective Study of Arbovirus Circulation in Northeast Brazil in 2019 and 2022: Insights into the Re-Emergence of DENV-3 and the Co-Infection of DENV-1 and CHIKV. [PDF]
VirusesArboviruses transmitted by Aedes aegypti cause high number of cases and deaths annually. The aim was to investigate the presence of the presence of Dengue (DENV), Zika (ZIKV) and Chikungunya (CHIKV) viruses in endemic areas of Maranhão, northeastern Brazil. The study was carried out in Caxias, Codó, Peritoró, and São Mateus do Maranhão in 2019 (Caxias)
Sousa SSDS +9 more
europepmc +5 more sources
Comparison of the FDA-Approved CDC DENV-1-4 Real-Time Reverse Transcription-PCR with a Laboratory-Developed Assay for Dengue Virus Detection and Serotyping [PDF]
Journal of Clinical Microbiology, 2013 ABSTRACT Dengue virus (DENV) is the agent of the most common vector-borne disease worldwide. Using 199 clinical samples collected from Nicaragua and Sri Lanka, a laboratory-developed DENV multiplex real-time reverse transcription-PCR (rRT-PCR) proved more clinically sensitive than the FDA-approved CDC assay for DENV serotypes 1 to 4 when ...
Jesse J. Waggoner +11 more
semanticscholar +5 more sources
Molecular docking NS4B of DENV 1-4 with known bioactive phyto-chemicals [PDF]
Bioinformation, 2016 Dengue disease is a global disease that has no effective treatment. The dengue virus (DENV) NS4B is a target for designing specific antivirals due to its importance in viral replication.
Anubrata Paul, A. Vibhuti, Samuel Raj
semanticscholar +4 more sources
Natural History of Dengue Virus (DENV)–1 and DENV‐4 Infections: Reanalysis of Classic Studies [PDF]
The Journal of Infectious Diseases, 2007 The natural history of wild-type dengue virus (DENV) infections of humans, including incubation and infectious periods, requires further study.Two experimental studies in the Philippines of DENV-4 (1924-1925) and DENV-1 (1929-1930) were reexamined. The intrinsic incubation periods were fitted to log-normal distribution using the maximum likelihood ...
Hiroshi Nishiura, Scott B. Halstead
semanticscholar +7 more sources
DENV-1 Titer Impacts Viral Blocking in wMel Aedes aegypti with Brazilian Genetic Background. [PDF]
VirusesSeveral countries have been using Wolbachia deployments to replace highly competent native Aedes aegypti populations with Wolbachia-carrying mosquitoes with lower susceptibility to arboviruses such as dengue, Zika, and chikungunya. In Rio de Janeiro, Wolbachia deployments started in 2015 and still present a moderate introgression with a modest ...
Corrêa-Antônio J +6 more
europepmc +6 more sources
Evolutionary history and spatiotemporal dynamics of DENV-1 genotype V in the Americas.
Infection, Genetics and Evolution, 2016 The genotype V has been the most prevalent dengue virus type 1 (DENV-1) clade circulating in the Americas over the last 40years. In this study, we investigate the spatiotemporal pattern of emergence and dissemination of DENV-1 lineages in the continent.
Fernanda de Bruycker-Nogueira +3 more
semanticscholar +4 more sources
Phylogenetic analysis of DENV-1 isolated in Surabaya, Indonesia
Journal of Bio-molecule Research And Engineering, 2022 Dengue virus (DENV1-4) belongs to the Flaviviridae family, which is transmitted by the Aedes mosquito vector and is the main cause of dengue fever and dengue hemorrhagic fever.
Fistara Lesti Rahmafitria +6 more
semanticscholar +2 more sources
Identification of Dengue Type 1 Virus (DENV-1) in Koreans Traveling Abroad
Osong Public Health and Research Perspectives, 2011 To date, no indigenous dengue virus (DENV) transmissions have been reported in Korea. However, imported dengue infections have been diagnosed in travelers returning from endemic areas. This study presents the first virological evidence of travel-associated DENV importation into South Korea.From January 2004 to June 2006, a total of 278 serum samples ...
Young Eui Jeong +4 more
semanticscholar +5 more sources
Genomic analysis of dengue virus serotype 1 (DENV-1) genotypes from Surabaya, Indonesia [PDF]
Virus Genes, 2018 Dengue has caused a significant public health impact globally. With the diverse genetic of the causative viruses, analysis of dengue virus (DENV) genomes is important to supplement epidemiological data with information that can be used to reconstruct the history of epidemics in time and space.
B. Yohan +4 more
semanticscholar +5 more sources