Results 21 to 30 of about 29,720,759 (240)

Retrospective Study of Arbovirus Circulation in Northeast Brazil in 2019 and 2022: Insights into the Re-Emergence of DENV-3 and the Co-Infection of DENV-1 and CHIKV. [PDF]

Viruses
Sousa SSDS, Cruz ACR, Aragão CF, Cereja GJGP, Silva SPD, Sousa RMM, Amorim MT, da Silva EVP, Nunes BTD, Pinheiro VCS.   +9 more
europepmc   +2 more sources

A Comparative Analysis of the Immunotranscriptomic Features of DENV-1, -3, and -4 Human Challenge Models

The Journal of Infectious Diseases
Abstract Background Dengue virus (DENV) infections cause a range of clinical symptoms, from a mild febrile illness to severe disease. Higher levels of DENV RNAemia are associated with severe dengue, although this relationship is incompletely understood. Dengue human infection models (DHIMs), in
Céline S. C. Hardy, Lisa A. Ware, Heather Friberg, Joel V. Chua, Kirsten E. Lyke, Stephen James Thomas, Adam Tully Waickman   +6 more
  +4 more sources

MicroRNA profiling of mouse liver in response to DENV-1 infection by deep sequencing. [PDF]

PeerJ, 2019
BackgroundDengue caused by dengue virus (DENV) serotypes −1 to −4 is the most important mosquito-borne viral disease in the tropical and sub-tropical countries worldwide. Yet many of the pathophysiological mechanisms of host responses during DENV infection remain largely unknown and incompletely understood.MethodsUsing a mouse model, the miRNA ...
Pong LY, Parkkinen S, Dhanoa A, Gan HM, Wickremesinghe IAC, Syed Hassan S.   +5 more
europepmc   +4 more sources

Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. [PDF]

PLoS Negl Trop Dis, 2018
The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage.
Pinheiro TM, Mota MTO, Watanabe ASA, Biselli-Périco JM, Drumond BP, Ribeiro MR, Vedovello D, Araújo JP, Pimenta PFP, Chaves BA, Silva MMCD, Batista ICA, Papa MP, Meuren LM, Lucas CGO, Matassoli FL, Gil LHVG, Bozzi A, Calzavara-Silva CE, Arruda LB, Souza DDG, Teixeira MM, Vasilakis N, Nogueira ML.   +23 more
europepmc   +6 more sources

Dengue and climate changes: Increase of DENV-1 in São Paulo/Brazil – 2023

Travel Medicine and Infectious Disease, 2023
Dengue is a vector borne disease caused by virus serotypes DENV-1, DENV-2, DENV-3, and DENV-4, representing a significant public health concern in the Region of the Americas (2,997,097 cases in 2023). This study explores the relationship between dengue incidence and climate changes in the city of São Paulo-Brazil.
Dennis Minoru Fujita, Felipe Scassi Salvador, Luiz Henrique da Silva Nali, Heitor Franco de Andrade   +3 more
openalex   +4 more sources

A Six Years (2010–2016) Longitudinal Survey of the Four Serotypes of Dengue Viruses in Lao PDR

Microorganisms, 2023
Dengue fever is the most prevalent arthropod-borne viral infection of humans in tropical and subtropical countries. Since 1979, dengue has been reported to be endemic in the Lao People’s Democratic Republic (PDR), as in many countries in Southeast Asia ...
Charlotte Balière, Elodie Calvez, Jean-Michel Thiberge, Somphavanh Somlor, Mathias Vandenbogaert, Marc Grandadam, Valérie Caro   +6 more
doaj   +1 more source

Envelope domain III E₃₂₄, E₃₅₁, and E₃₈₀ mutations lever adaptive evolution of DENV-1 genotype I. [PDF]

J Virol
Jiang T, Huang C, Ruan Q, Huang X, Liang C, Chen Z, Yu X, Peng Y, Liu Z, Cheng G, Dai J, Sun J.   +11 more
europepmc   +3 more sources

Molecular Characterization of Dengue Virus Strains from the 2019–2020 Epidemic in Hanoi, Vietnam

Microorganisms, 2023
Dengue virus (DENV), which has circulated in Vietnam for several decades, has multiple serotypes and genotypes. A 2019 dengue outbreak resulted in a larger number of cases than any other outbreak.
Juthamas Phadungsombat, Huong Thi Thu Vu, Quynh Thi Nguyen, Ha Thi Van Nguyen, Ha Thi Nhu Nguyen, Bich Thi Dang, Emi E. Nakayama, Azumi Ishizaki, Hiroshi Ichimura, Tatsuo Shioda, Thach Ngoc Pham   +10 more
doaj   +1 more source

Discrepant Activation Pattern of Inflammation and Pyroptosis Induced in Dermal Fibroblasts in Response to Dengue Virus Serotypes 1 and 2 and Nonstructural Protein 1

Microbiology Spectrum, 2023
Four serotypes of dengue virus (DENV-1 to DENV-4) cause mild to severe disease in humans through infected mosquito bites. Dermal fibroblasts were found to be susceptible to DENV, and this may play a critical role in establishing the initial infection ...
Kai-Che Wei, Wan-Ju Wei, Ching-Len Liao, Tsung-Hsien Chang   +3 more
doaj   +1 more source

Viral Dynamic Model-Informed Dose Selection of Mosnodenvir Prophylaxis against DENV-3 in a Controlled Human Infection Model. [PDF]

Clin Pharmacol Ther
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Goeyvaerts N, de Trixhe XW, Neyens M, Kakuda TN, Van Wesenbeeck L, Buelens A, Rasschaert F, Durbin A, Ackaert O.   +8 more
europepmc   +2 more sources