Results 11 to 20 of about 14,576 (79)

Sm16, A Schistosoma mansoni Immunomodulatory Protein, Fails to Elicit a Protective Immune Response and Does Not Have an Essential Role in Parasite Survival in the Definitive Host

open access: yesJournal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
Sm16 is an immunomodulatory protein that seems to play a key role in the suppression of the cutaneous inflammatory response during Schistosoma mansoni penetration of the skin of definitive hosts. Therefore, Sm16 represents a potential target for protective immune responses induced by vaccination. In this work, we generated the recombinant protein rSm16
Wilma Patrícia de Oliveira Santos Bernardes   +11 more
wiley   +1 more source

The STENOFOLIA gene from Medicago alters leaf width, flowering time and chlorophyll content in transgenic wheat

open access: yesPlant Biotechnology Journal, Volume 16, Issue 1, Page 186-196, January 2018., 2018
Summary Molecular genetic analyses revealed that the WUSCHEL‐related homeobox (WOX) gene superfamily regulates several programs in plant development. Many different mechanisms are reported to underlie these alterations. The WOX family member STENOFOLIA (STF) is involved in leaf expansion in the eudicot Medicago truncutula.
Meiyan Liu   +8 more
wiley   +1 more source

Recombinant production of Zymomonas mobilis pyruvate decarboxylase in the haloarchaeon Haloferax volcanii

open access: yesArchaea, Volume 1, Issue 5, Page 327-334, 2005., 2005
The unusual physiological properties of archaea (e.g., growth in extreme salt concentration, temperature and pH) make them ideal platforms for metabolic engineering. Towards the ultimate goal of modifying an archaeon to produce bioethanol or other useful products, the pyruvate decarboxylase gene of Zymomonas mobilis (Zm pdc) was expressed in Haloferax ...
Steven J. Kaczowka   +3 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, Volume 600, Issue 15, Page 2129-2142, August 2026.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

Computational design of a soluble mimic of the outer membrane LPS transport protein LptD suitable for screening of antibiotics

open access: yesProtein Science, Volume 35, Issue 6, June 2026.
Abstract Lipopolysaccharides (LPS) are the principal chemical component of the outer leaflet of Gram‐negative bacteria and constitute the first barrier of defense against foreign molecules. Inhibition of LPS transport presents a novel concept for antibiotic discovery, and components of the transport bridge are targets of antimicrobial peptides. LptD, a
Wenzhao Dai   +5 more
wiley   +1 more source

Roles of Alp and Prt Regulons in the Response of Pseudomonas aeruginosa to UV‐C Light

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Our results show that LexA‐regulated genes are the first to be induced after DNA damage, while autolysis functions controlled by the Alp system are the last. Death by UV is mediated primarily by Alp or Prt systems, depending on the Pseudomonas aeruginosa subline. ABSTRACT UV light is a well‐studied environmental DNA damaging agent.
Marina R. B. Fonseca   +6 more
wiley   +1 more source

Characterization and Antibody Preparation of the Gene Products of Grouper Iridovirus ORF5L

open access: yesAquaculture, Fish and Fisheries, Volume 5, Issue 6, December 2025.
ABSTRACT Grouper iridovirus (GIV) is a large DNA virus belonging to the family Iridoviridae and genus Ranavirus. It consists of 139,793 base pairs (bp) and 120 open reading frames (ORFs). GIV is a key pathogen of farmed fish worldwide. The functional roles of viral genes must be determined for the early diagnosis, treatment and prevention of viral ...
Chu‐Fan Cheng   +2 more
wiley   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

open access: yesThe FEBS Journal, Volume 292, Issue 19, Page 5105-5129, October 2025.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés   +19 more
wiley   +1 more source

Structure and Stability of Ago2 MID‐Nucleotide Complexes: All‐in‐One (Drop) His6‐SUMO Tag Removal, Nucleotide Binding, and Crystal Growth

open access: yesCurrent Protocols, Volume 4, Issue 6, June 2024.
Abstract The middle (MID) domain of eukaryotic Argonaute (Ago) proteins and archaeal and bacterial homologues mediates the interaction with the 5′‐terminal nucleotide of miRNA and siRNA guide strands. The MID domain of human Ago2 (hAgo2) is comprised of 139 amino acids with a molecular weight of 15.56 kDa.
Li Lei   +6 more
wiley   +1 more source

GTP‐dependent regulation of heterochromatin fluctuations at subtelomeric regions in Saccharomyces cerevisiae

open access: yesGenes to Cells, Volume 29, Issue 3, Page 217-230, March 2024.
We discovered that IMD2, which plays a role in GTP synthesis, is expressed by alterations in the heterochromatin region as a response to reduced GTP levels. Abstract In eukaryotes, single cells in a population display different transcriptional profiles. One of the factors regulating this heterogeneity is the chromatin state in each cell.
Takahito Ayano   +2 more
wiley   +1 more source

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