Results 1 to 10 of about 13,337 (203)
FleQ-Dependent regulation of the ribonucleotide reductase repressor NrdR in Pseudomonas aeruginosa during biofilm growth and infection [PDF]
Scientific ReportsRibonucleotide reductases (RNRs) are essential enzymes that catalyze the conversion of ribonucleotides to deoxyribonucleotides (dNTPs), a critical step in DNA synthesis and repair.
Domingo Marchan +6 more
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The effect of chlorination of nucleotide bases on the conformational properties of thymidine monophosphate [PDF]
The Ukrainian Biochemical Journal, 2015 Recent studies on Escherichia coli bacteria cultivation, in which DNA thymine was replaced with 5-chlorouracil have refreshed the problem of understanding the changes to physical properties of DNA monomers resultant from chemical modifications.
T. M. Mukhina, T. Yu. Nikolaienko
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A Novel One-Pot Enzyme Cascade for the Biosynthesis of Cladribine Triphosphate
Biomolecules, 2021 Cladribine triphosphate is the active compound of the anti-cancer and multiple sclerosis drug Mavenclad (cladribine). Biosynthesis of such non-natural deoxyribonucleotides is challenging but important in order to study the pharmaceutical modes of action.
Julia Frisch +2 more
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PLoS ONE, 2022 Ribonucleotide reductases (RNRs) use radical-based chemistry to catalyze the conversion of all four ribonucleotides to deoxyribonucleotides. The ubiquitous nature of RNRs necessitates multiple RNR classes that differ from each other in terms of the ...
Talya S. Levitz +5 more
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Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication. [PDF]
PLoS Computational Biology, 2011 Using a computational model, we simulated mitochondrial deoxynucleotide metabolism and mitochondrial DNA replication. Our results indicate that the output from the mitochondrial salvage enzymes alone is inadequate to support a mitochondrial DNA ...
Vishal V Gandhi, David C Samuels
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Deoxyribonucleotide Pools during Liver Regeneration [PDF]
European Journal of Biochemistry, 1973 The intracellular pools of deoxyribonucleotides were analyzed during liver regeneration in rats. In normal liver the content of dATP, dCTP, dGTP and dTTP was found to be 0.3, 1.3, 0.3 and 0.4 pmol per μg DNA, respectively. When the liver tissue started to proliferate the pools of the individual deoxyribonucleoside triphosphates increased and reached ...
S S, Söderhäll, A, Larsson, K L, Skoog
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eLife, 2023 Life requires ribonucleotide reduction for de novo synthesis of deoxyribonucleotides. As ribonucleotide reduction has on occasion been lost in parasites and endosymbionts, which are instead dependent on their host for deoxyribonucleotide synthesis, it ...
Samantha DM Arras +11 more
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Journal of Pharmaceutical Analysis, 2020 Accurate DNA quantitation is a prerequisite in many biomedical and pharmaceutical studies. Here we established a new DNA quantitation method by nuclease P1 digestion and UPLC-MS/MS analysis.
Yong Ma, Buyun Chen, Donglu Zhang
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The Origin and Evolution of Ribonucleotide Reduction
Life, 2015 Ribonucleotide reduction is the only pathway for de novo synthesis of deoxyribonucleotides in extant organisms. This chemically demanding reaction, which proceeds via a carbon-centered free radical, is catalyzed by ribonucleotide reductase (RNR).
Daniel Lundin +3 more
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Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts. [PDF]
PLoS ONE, 2009 BackgroundOncogene activation plays a role in metabolic reprogramming of cancer cells. We have previously shown that K-ras transformed fibroblasts have a stronger dependence on glycolysis and a reduced oxidative phosphorylation ability as compared to ...
Daniela Gaglio +4 more
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