Results 101 to 110 of about 13,337 (203)
Fine-scale population structure and asymmetrical dispersal in an obligate salt-marsh passerine, the Saltmarsh Sparrow (Ammodramus Caudacutus) [PDF]
, 2012 Understanding the spatial scale of gene flow can yield valuable insight into the ecology of an organism and guide conservation strategies. Fine-scale genetic structure is uncommon in migratory passerines because of their high vagility and presumed high ...
Babbitt, Kimberly J. +3 more
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Cell cycle specific radiosensitisation by the disulfiram and copper complex [PDF]
, 2017 The disulfiram and copper complex (DSF:Cu) has emerged as a potent radiosensitising anti-cancer agent. The ability of copper to stabilise DSF in a planar conformation and to inhibit DNA replication enzymes stimulated our investigation of the effect of
Anselmi, Giorgio +3 more
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Deoxyribonucleotide salvage falls short in whole animals [PDF]
Journal of Biological Chemistry, 2019 Ribonucleotide reductase (RNR) catalyzes the first committed reaction in DNA synthesis. Most of what we know about RNR regulation comes from studies with cultured cells and with purified proteins. In this study, Tran et al. use Cre-Lox technology to inactivate RNR large subunit expression in heart and skeletal muscle of mouse embryos. Analysis of these
openaire +2 more sources
Molecular Therapy: Nucleic Acids, 2018 Pancreatic cancer is currently one of the deadliest of the solid malignancies, whose incidence and death rates are increasing consistently during the past 30 years.
Shuquan Zheng +15 more
doaj +1 more source
PLoS ONE, 2013 Infection with hepatitis C virus (HCV) is etiologically involved in liver cirrhosis, hepatocellular carcinoma and B-cell lymphomas. It has been demonstrated previously that HCV non-structural protein 3 (NS3) is involved in cell transformation.
Chiu-Ping Fang +8 more
doaj +1 more source
Kinetic Features of 3′-5′ Exonuclease Activity of Human AP-Endonuclease APE1
Molecules, 2018 Human apurinic/apyrimidinic (AP)-endonuclease APE1 is one of the key enzymes taking part in the repair of damage to DNA. The primary role of APE1 is the initiation of the repair of AP-sites by catalyzing the hydrolytic incision of the phosphodiester bond
Alexandra A. Kuznetsova +2 more
doaj +1 more source
Buffering of deoxyribonucleotide pool homeostasis by threonine metabolism [PDF]
Proceedings of the National Academy of Sciences, 2007 Synergistically interacting gene mutations reveal buffering relationships that provide growth homeostasis through their compensation of one another. This analysis in Saccharomyces cerevisiae revealed genetic modules involved in tricarboxylic acid cycle regulation ( RTG1 , RTG2
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Investigation of the covalent binding of styrene-7,8-oxide to DNA in rat and mouse [PDF]
, 2017 Styrene-7,8-oxide (SO), the main intermediate metabolite of styrene, induces hyperkeratosis and tumors in the fore-stomach of rats and mice upon chronic administration by gavage.
Cantoreggi, S., Lutz, W.K.
core
Metabolism of Deoxyribonucleotides
Journal of Biological Chemistry, 1966 Hiroyuki Nakamura, Yukio Sugino
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The Problem of the "Prebiotic and Never Born Proteins"
, 2012 It has been argued that the limited set of proteins used by life as we know it could not have arisen by the process of Darwinian selection from all possible proteins.
Berg +7 more
core +1 more source