Results 171 to 180 of about 13,337 (203)

Enhanced Protein Precipitation with Ammonia Enables Rapid, Universal Extraction of Oligonucleotides for Bioanalysis. [PDF]

ACS Omega
Kamali A, Shelke JD, Sanford EJ, Hayashi MM, Chaisakhon N, Kolakowski RV, Puri S, Zhang G.   +7 more
europepmc   +1 more source

Unraveling the role of bacteria with heritable versus non-heritable relative abundance in the gut on boar semen quality. [PDF]

Genet Sel Evol
Guo L, Pei X, Tan J, Sun H, Jiang S, Wei H, Peng J.   +6 more
europepmc   +1 more source

The XNA alphabet. [PDF]

Nucleic Acids Res
Chaput JC, Egli M, Herdewijn P.
europepmc   +1 more source

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes. [PDF]

Nat Microbiol
Medvedeva S, Guyet U, Pelletier E, Ruscheweyh HJ, Sunagawa S, Ogata H, Aylward FO, Gaïa M, Yutin N, Koonin EV, Krupovic M, Delmont TO.   +11 more
europepmc   +1 more source

Poly(G)₇ box: a functional element of mammalian 18S rRNA involved in translation. [PDF]

RNA Biol
Wei D, Mai Z, Li X, Yu T, Li J.
europepmc   +1 more source

Selective Acetalization in Pyridine: A Sustainable 5'-<i>O</i>-(2-Methoxypropyl) Protecting Group in the Synthesis of Nucleic Acid Analogs. [PDF]

Org Lett
Saari V, Eerola A, Ora M, Gimenez Molina A, Horvath A, Sanghvi YS, Virta P.   +6 more
europepmc   +1 more source

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Acidic hydrolysis of pyrimidine deoxyribonucleotides

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract The rates of acidic N-glycosyl cleavage of the 3′- and 5′-phosphates of deoxycytidine and thymidine have been studied. The pH-rate profiles and thermodynamic parameters for the hydrolyses resemble those of the parent nucleosides. It is likely that the A-1 mechanism observed with the nucleosides also operates at the nucleotide level.
R, Shapiro, M, Danzig
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Mutagenesis and deoxyribonucleotide pool imbalance

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988
Numerous studies have demonstrated that DNA-precursor pool imbalances are mutagenic and can modulate the lethality and mutagenicity of DNA-damaging agents. In addition, physical and chemical mutagens can induce alterations in DNA-precursor levels.
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Fishing in the (deoxyribonucleotide) pool

Biochemical Journal, 2009
Deoxyribonucleoside triphosphates (dNTPs) are the building blocks of DNA, and a constant supply is essential for the synthesis and maintenance of both the nuclear and mitochondrial genomes. Antiviral nucleoside analogues and inborn errors of nucleotide metabolism frequently cause dNTP pool imbalances, leading to depletion of mtDNA (mitochondrial DNA ...
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Deoxyribonucleotide metabolism, mutagenesis and cancer

Nature Reviews Cancer, 2015
Cancer was recognized as a genetic disease at least four decades ago, with the realization that the spontaneous mutation rate must increase early in tumorigenesis to account for the many mutations in tumour cells compared with their progenitor pre-malignant cells.
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