Results 181 to 190 of about 13,337 (203)

The Biosynthesis of Deoxyribonucleotides

2004
Ribonucleotide reductases play a central role in DNA biosynthesis. They catalyze the conversion of NDPs (NTPs) to dNDPs (dNTPs) concomitant with oxidation of thiols within their active sites. A single active site can accomodate reduction of both purine and pyrimidine nucleotides.
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MODULATION OF MUTAGENESIS BY DEOXYRIBONUCLEOTIDE LEVELS

Annual Review of Genetics, 1991
INTRODUCTION .,' . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 D E NO VO dNTP S yNTHESIS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . .
B A, Kunz, S E, Kohalmi
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3'-Deoxyribonucleotides Inhibit Eukaryotic DNA Primase

Journal of Biochemistry, 1996
In order to elucidate the biological activities of cordycepin (3'-deoxyadenosine) and related 3'-deoxyribonucleosides on eukaryotic DNA replication, the inhibitory effects of triphosphate derivatives of 3'-deoxyadenosine(3'-dATP), 8-azido-3'-deoxyadenosine(8-N3-3'-dATP), 3'-deoxyguanosine(3'-dGTP), 3'deoxyuridine(3'dUTP), 5-fluoro-3'deoxyuridine(5-F-3'-
S, Izuta, M, Kohsaka-Ichikawa, T, Yamaguchi, M, Saneyoshi   +3 more
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Ribonucleotide Reductase and Deoxyribonucleotide Pools

1985
Ribonucleotide reductase plays a crucial role in the maintenance of dNTP pools. A molecular model for the allosteric regulation of the enzyme is substantiated by the effects of nucleosides or inhibitors on pool sizes in intact cells as well as by manifestations of mutations of the reductase and other enzymes involved in deoxynucleoside metabolism ...
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Genetic effects of deoxyribonucleotide pool imbalances

Environmental Mutagenesis, 1982
AbstractIn vivo DNA precursor imbalances can have profound genetic consequences in prokaryotes and eukaryotes. In vitro studies have demonstrated that DNA replication fidelity is dependent on correct balances of deoxyribonucleoside triphosphates during DNA synthesis.
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On the Regulation of Deoxyribonucleotide Synthesis

1985
The results reviewed here demonstrate the feasibility of measuring the turnover of pyrimidine dNTPs in cultured cells and of relating such data to rates of DNA synthesis. Growing 3T6 cells appear to contain two kinetically distinct pools of dCTP. One pool is preferentially labeled by reduction of CDP and used for DNA synthesis, the second pool is ...
P, Reichard, B, Nicander
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Deoxyribonucleotides and Disorders of Mitochondrial DNA Integrity

DNA and Cell Biology, 2004
Mitochondrial DNA (mtDNA) depends on numerous nuclear encoded factors and a constant supply of deoxyribonucleoside triphosphates (dNTP), for its maintenance and replication. The function of proteins involved in nucleotide metabolism is perturbed in a heterogeneous group of disorders associated with depletion, multiple deletions, and mutations of the ...
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Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency

Molecular Genetics and Metabolism, 2008
Mutated deoxyguanosine kinase (dGK), which catalyses the first step of the mitochondrial deoxypurine salvage pathway, accounts for a hepatocerebral variant of mitochondrial DNA (mtDNA) depletion syndromes. In order to elucidate the pathogenic mechanism of dGK deficiency, mitochondrial and cytoplasmic deoxyribonucleoside triphosphate (dNTP) pools in ...
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Biosynthesis of Deoxyribonucleotides in Ochromonas malhamensis

The Journal of Protozoology, 1971
SYNOPSIS. Uniformly 14C‐labeled pyrimidine ribonucleosides and orotic‐6‐14C acid were fed to growing cultures of Ochromonas malhamensis and the radioactivity appearing in RNA and DNA was determined. The carbon skeletons of uridine and cytidine were incorporated intact into all of the pyrimidine nucleotides from RNA and DNA.
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Metaphysics of regulated deoxyribonucleotide biosynthesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988
R H, Haynes, B A, Kunz
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