Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli. [PDF]
PLoS ONE, 2012 Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair.
Maria del Mar Cendra +2 more
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Pathogen-driven nucleotide overload triggers mitochondria-centered cell death in phagocytes.
PLoS Pathogens, 2023 Staphylococcus aureus is a dangerous pathogen that evolved refined immuno-evasive strategies to antagonize host immune responses. This involves the biogenesis of death-effector deoxyribonucleosides, which kill infectious foci-penetrating macrophages ...
Nicoletta Schwermann +4 more
doaj +1 more source
Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants [PDF]
, 2016 Despite recent advances in understanding the complexity of RNA processes, regulation of the metabolism of oxidized cellular RNAs and the mechanisms through which oxidized ribonucleotides affect mRNA translation, and consequently cell viability, are not ...
A Nunomura +36 more
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Enzymatic Synthesis of Deoxyribonucleotides [PDF]
European Journal of Biochemistry, 1967 Deoxycytidine diphosphate was synthesized in [2H2] water from cytidine diphosphate with the ribonucleoside diphosphate reductase system from Escherichia coli B. After dephosphorylation and crystallization, deoxycytidine was analyzed by nuclear magnetic resonance at 60 and 100 megaHertz.
L. J. Durham, A. Larsson, P. Reichard
openaire +2 more sources
Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair [PDF]
, 2013 Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast, low-fidelity Escherichia coli DNA polymerase V (pol V) has relatively poor sugar discrimination and ...
A Vaisman +77 more
core +3 more sources
Sequence specific binding of beta carboline alkaloid harmalol with deoxyribonucleotides: binding heterogeneity, conformational, thermodynamic and cytotoxic aspects. [PDF]
PLoS ONE, 2014 Base dependent binding of the cytotoxic alkaloid harmalol to four synthetic polynucleotides, poly(dA).poly(dT), poly(dA-dT).poly(dA-dT), poly(dG).poly(dC) and poly(dG-dC).poly(dG-dC) was examined by various photophysical and calorimetric studies, and ...
Sarita Sarkar +2 more
doaj +1 more source
Raman depolarization ratios in RNA and DNA are sensitive for sugar-base coupling [PDF]
, 1995 Polarized and depolarized Raman spectra are obtained for a number of synthetic polynucleotides containing adenine, uracil, and thymine bases. The depolarization ratios are determined by two methods: (1) by dividing the -spectrum by the -spectrum and (2 ...
Benevides +17 more
core +3 more sources
The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism
Journal of Nucleic Acids, 2010 Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria.
Claus Desler +2 more
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Neoplasia: An International Journal for Oncology Research, 2021 Ribonucleotide reductase (RNR) is the key enzyme that catalyzes the production of deoxyribonucleotides (dNTPs) for DNA replication and it is also essential for cancer cell proliferation.
Ling Tian +15 more
doaj +1 more source
Journal of Biomedical Science, 2022 Background Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these pathways could be therapeutically exploited. Ribonucleotide reductase (
Yongsheng Xie +19 more
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