Results 31 to 40 of about 13,337 (203)
Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters
eLife, 2022 Replication of the genome must be coordinated with gene transcription and cellular metabolism, especially following replication stress in the presence of limiting deoxyribonucleotides.
Yi-Jun Sheu +3 more
doaj +1 more source
Metabolic Origin, Role and Fate of the Denaturant Guanidine. [PDF]
Microb BiotechnolThe origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Danchin A +3 more
europepmc +2 more sources
Optimization of Chemical Defined Medium for <i>Lactobacillus brevis</i> Based on Artificial Intelligence. [PDF]
Eng Life SciABSTRACT Lactobacillus brevis (L. brevis) is a bacterium known for its lactic acid production and probiotic properties. However, the limited research on industrial fermentation of L. brevis and its low productivity pose challenges. This work aimed to develop a cost‐effective synthetic medium as an alternative to a complex medium for its large‐scale ...
Yu C, Yang X, Ren X, Xia J.
europepmc +2 more sources
A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. [PDF]
, 2010 Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the ...
Ashihara, Eishi +13 more
core +1 more source
RRM2B: An oxygen-requiring protein with a role in hypoxia
Molecular & Cellular Oncology, 2017 How tumor cells adapt and survive under hypoxia significantly impacts patient prognosis. We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen ...
Iosifina P. Foskolou, Ester M. Hammond
doaj +1 more source
Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. [PDF]
PLoS ONE, 2014 Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. We show that ataxia telangiectasia mutated (ATM) integrates the DNA damage response with DNA metabolism by regulating the salvage of deoxyribonucleosides ...
Yuri L Bunimovich +7 more
doaj +1 more source
mSystems, 2023 Ribonucleotide reductases (RNRs) are key enzymes which catalyze the synthesis of deoxyribonucleotides, the monomers needed for DNA replication and repair.
Alba Rubio-Canalejas +3 more
doaj +1 more source
The cyanobacterial ribosomal-associated protein LrtA from Synechocystis sp. PCC 6803 is an oligomeric protein in solution with chameleonic sequence properties [PDF]
, 2018 The LrtA protein of Synechocystis sp. PCC 6803 intervenes in cyanobacterial post-stress survival and in stabilizing 70S ribosomal particles. It belongs to the hibernating promoting factor (HPF) family of proteins, involved in protein synthesis. In this
Contreras, Lellys M. +8 more
core +5 more sources
Unbalanced Deoxyribonucleotide Synthesis Caused by Methotrexate [PDF]
BMJ, 1972 The effect of methotrexate on the free intracellular pools of thymidylate triphosphate (dTTP) and deoxyadenosine triphosphate (dATP) in normal human phytohaemagglutinin-transformed lymphocytes has been studied. Methotrexate caused a fall in the dTTP pool ranging from 38% to 88% and a rise in the dATP pool ranging from 24% to 185%.A rise in the free ...
A V, Hoffbrand, E, Tripp
openaire +2 more sources
Journal of Pharmaceutical Analysis, 2022 Endogenous ribonucleotides (RNs) and deoxyribonucleotides (dRNs) are important metabolites related to the pathogenesis of many diseases. In light of their physiological and pathological significances, a novel and sensitive pre-column derivatization ...
Huixia Zhang +7 more
doaj +1 more source