Results 61 to 70 of about 13,337 (203)
eLife, 2016 Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by the ...
Christina M Zimanyi +4 more
doaj +1 more source
Pathogens, 2023 Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis.
Chee-Hing Yang +5 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Based on Mendelian randomization analysis, this study established a significant causal effect of irritable bowel syndrome (IBS) on increasing generalized anxiety disorder (GAD) risk (odds ratio = 1.328; p < 0.001) and identified dozens of gut microbial taxa, plasma metabolites, inflammatory factors, and immune cell characteristics with potential causal
Weili Yang +7 more
wiley +1 more source
Nucleotides: Structure and Properties [PDF]
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang +14 more
wiley +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.A simple and general photoactivatable approach is developed to regulate DNA polymerase activity, enabling light‐start isothermal amplification on demand. The molecular dynamics simulations reveals that the photocaged primer blocks DNA polymerase activity by inhibiting the conformational change of the polymerase.
Min Qing +7 more
wiley +1 more source
Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]
, 2017 Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio +1 more
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Advanced Science, Volume 13, Issue 1, 5 January 2026.An in situ moldable GelSSO/PDA@SDF hydrogel functions as a chronotaxic signal‐amplifying biomimetic niche to restore regenerative failure in diabetic cranial defects. By sequentially releasing SDF‐1α‐loaded PDA nanoparticles and osteoinductive oligodeoxynucleotides, it orchestrates immunomodulation, progenitor recruitment, angiogenesis, and ...
Yingji Mao +5 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2015 It was Francis Crick who first asked why the ribosome contains so much RNA, and discussed the implications of this for the direct flow of genetic information from DNA to protein.
Harold S Bernhardt, Warren P Tate
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Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source