Results 81 to 90 of about 13,337 (203)

A fiber-optic phase-randomizer for microscope illumination by laser [PDF]

, 1979
s of Papers Presented at the 19th Annual Meeting, The American Society for Cell Biology, Toronto, Ontario, Canada, November 4-8, 1979Author Posting. © Rockefeller University Press, 1979.
Ellis, Gordon W.
core  

Discrimination against Deoxyribonucleotide Substrates by Bacterial RNA Polymerase [PDF]

Journal of Biological Chemistry, 2004
Nucleic acid polymerases have evolved elaborate mechanisms that prevent incorporation of the non-cognate substrates, which are distinguished by both the base and the sugar moieties. While the mechanisms of substrate selection have been studied in single-subunit DNA and RNA polymerases (DNAPs and RNAPs, respectively), the determinants of substrate ...
Vladimir, Svetlov, Dmitry G, Vassylyev, Irina, Artsimovitch   +2 more
openaire   +2 more sources

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Interaction Between The MEC1-Dependent DNA Synthesis Checkpoint And G1 Cyclin Function In Saccharomyces Cerevisiae [PDF]

, 1999
The completion of DNA synthesis in yeast is monitored by a checkpoint that requires MEC1 and RAD53. Here we show that deletion of the Saccharomyces cerevisiae G1 cyclins CLN1 and CLN2 suppressed the essential requirement for MEC1 function.
Cross, F. R., Vallen, Elizabeth Ann
core   +1 more source

Impact of template backbone heterogeneity on RNA polymerase II transcription. [PDF]

, 2014
Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution.
Chong, Jenny, Huang, Xuhui, Wang, Dong, Wang, Wei, Xu, Liang, Zhang, Lu   +5 more
core   +1 more source

Deoxyribonucleotide Sequence Relationships Among Bordetella Species [PDF]

International Journal of Systematic Bacteriology, 1981
Deoxyribonucleotide sequence relationships among currently recognized Bordetella species (Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica) were examined by deoxyribonucleic acid (DNA) hybridization involving the hydroxyapatite batch procedures of Brenner and co-workers.
W. E. KLOOS, N. MOHAPATRA, W. J. DOBROGOSZ, J. W. EZZELL, C. R. MANCLARK   +4 more
openaire   +1 more source

Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down‐Regulated Senescent Epidermal Basal Cells

Arthritis &Rheumatology, Volume 77, Issue 12, Page 1713-1725, December 2025.
Objective This study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). Methods Cellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP ...
Sena Yamamoto, Yuki Saito, Tsukasa Sato, Seina Nakano, Dain Kasseki, Ayaka Nagao, Norihiro Miura, Kentaro Nagaoka, Arisa Kita, Maki Miyajima, Shogo Ijima, Koji Taniguchi, Atsushi Niida, Takako S. Chikenji   +13 more
wiley   +1 more source

Wider Than Expected: Geographic Range and Genetic Diversity of a Commercially Farmed and Traded “Cottonii” Seaweed Kappaphycus malesianus

Ecology and Evolution, Volume 15, Issue 12, December 2025.
The study expands the known distribution of Kappaphycus malesianus beyond the southern Philippines by documenting new wild populations in Luzon and Visayas through multilocus phylogenetic analyses. High genetic diversity, novel haplotypes, and a key genetic link between farmed and wild populations across distant regions were identified, revealing ...
Ronel T. Aguilar, Bea A. Crisostomo, Jonh Rey L. Gacura, Lourie Ann R. Hinaloc, Michael Y. Roleda   +4 more
wiley   +1 more source

Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia

British Journal of Haematology, Volume 207, Issue 6, Page 2462-2474, December 2025.
Left: Cells with active SAMHD1 can metabolize cytarabine (ara‐C) and fludarabine (F‐ara‐A) to their inactive precursors, limiting their cytotoxic effects. Right: Addition of hydroxyurea (hydroxycarbamide; HU) inhibits SAMHD1, leading to an increase in the active metabolites of ara‐C and F‐ara‐A and a subsequent increase in the cytotoxicity of these ...
Ingrid Lilienthal, Sijia Tao, Christer Nilsson, Elory Leonard, Runqing Zhang, Agnes L. Sorteberg, Louisa Fredrikson, Ioanna Xagoraris, Shahrzad Shirazi Fard, Nikolaos Tsesmetzis, Vasilios Zachariadis, Huan Cai, Lakshmi Sandhow, Anette Langebäck, Anna Bohlin, Katja Pokrovskaja Tamm, Sofia Bengtzén, Raymond F. Schinazi, Sören Lehmann, Baek Kim, Georgios Z. Rassidakis, Hong Qian, Martin Jädersten, Nikolas Herold   +23 more
wiley   +1 more source

The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters [PDF]

, 2014
The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitochondrial carrier family, many of which have been shown to transport inorganic anions, amino acids, carboxylates, nucleotides, and coenzymes across the inner
Agrimi, G., Cirigliano, A., Di Noia, M. A., Iacobazzi, V., Palmieri, Ferdinando, Rinaldi, T., Todisco, S.   +6 more
core   +2 more sources