MGL‐Based Drug Conjugate: A Novel Glycan‐Targeting Strategy for Potential Precision Cancer Therapy
An engineered macrophage galactose‐type lectin (MGL)‐based conjugate (mMGL‐vcMMAE), incorporating an exposed cysteine for site‐specific drug linkage, preserves stability, binding profile, and affinity of the native MGL carbohydrate recognition domain. It also selectively targets Tn/STn‐expressing cancer cells and shows recognition of colorectal cancer ...
Carlos D. L. Lima +15 more
wiley +1 more source
Efficient EM Estimation for the Pogit Model via Polya-Gamma Augmentation. [PDF]
Gutiérrez I, Ramírez S, Jofré L.
europepmc +1 more source
Instrucción general del Organismo intermedio a los Organismos colaboradores para la gestión y procedimiento de las operaciones cofinanciadas por el Programa Operativo FSE 2007-2013 [PDF]
Gobierno de Aragón. Departamento de Economía, Hacienda y Empleo
core
Hair Cortisol Concentrations in Children: A Longitudinal Analysis Across Childhood
ABSTRACT Hair cortisol concentration (HCC) reflects long‐term cortisol exposure and is commonly used as a biomarker of hypothalamic–pituitary–adrenal axis activity. Although increasingly applied in pediatric populations, developmental changes in HCC and potential sex differences remain unclear.
Miguel Ángel Baos‐González +4 more
wiley +1 more source
Organic periostracum preserved in Cretaceous ammonoids from the Andean Neuquén Basin. [PDF]
Aguirre-Urreta B +9 more
europepmc +1 more source
Telomere dynamics in ectotherms remain poorly understood relative to endotherms, yet are increasingly relevant in the context of climate change. Here, we used model‐averaged GLMMs and hierarchical partitioning to disentangle intrinsic and extrinsic drivers of relative telomere length in the Western‐Canaries Lizard (Gallotia galloti) across a 10‐year ...
Edward Gilbert +9 more
wiley +1 more source
Evidence-Based Monitoring of Prodiplosis longifila in Foliage Crops: Damage, Economic Impact, Trapping Tools, and Population Dynamics. [PDF]
Naranjo-Serrato AN +4 more
europepmc +1 more source
Iniciativas para la eliminación de todas las formas de discriminación contra la mujer / Karen Duke [PDF]
Duke, Karen +1 more
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Reprogrammable All‐Photonic Molecular Logic With Ln3+ Luminescent Hybrids in Solid State
Mario P. de‐Saralegui et al. report an Eu3⁺/Tb3⁺‐doped organic–inorganic hybrid material that enables multiple reprogrammable logic operations using only physical stimuli. Additionally, this solid‐state, all‐photonic platform represents the first example in the literature performing reversible Feynman logic operations, marking a major step toward ...
Mario P. de‐Saralegui +4 more
wiley +1 more source
Association between cognitive function, socio-clinical factors and biomarkers among Panamanian adults living with and without HIV: A cross-sectional study. [PDF]
Castillo Mewa J +13 more
europepmc +1 more source

