Results 81 to 90 of about 1,056,131 (268)

The role of the control of “life’s essential 8” for prevention on heart failure and all-cause mortality in patients with hypertension: the Kailuan cohort study

BMC Public Health
Background Hypertension can lead to an increased risk of heart failure and death. The life’s essential 8 (LE8) is an eight-factor measure of cardiovascular health recently released by the American Heart Association for use in measuring cardiovascular ...
Jing Wang, Shuilin Wu, Liuxin Li, Jing Wu, Shiqiu Meng, Xueying Qin, Xin Chen, Shoulin Wu, Jie Shi, Yanping Bao, Feng Wang   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Cognition of Palliative Care and Experience of Palliative Sedation in Chinese Anesthesiologists: A National Cross-sectional Survey

Xiehe Yixue Zazhi
Objective  This study aimed to investigate Chinese anesthesiologists' comprehension of palliative care and their experiences with palliative sedation for patients in the end-stage of life.
YU Jiawen, LIU Hongju, XU Yingying, BAO Yanping, SHI Jie, LIU Zhimin, ZHANG Yuelun, NING Xiaohong, HUANG Yuguang   +8 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Developing the Guideline of Therapeutic Interventions for Street Children With Substance Use Disorders

Iranian Rehabilitation Journal, 2018
Millions of children are left to survive on the streets around the world. Investigations on drug use disorders among street children reveal that they not only abuse all types of drugs higher than their peers who live at home or in shelters, but also they
Nastaran Habibi, Mahboobe Firoozkoohi Moghaddam, Elham Salari, Nasrin Dodangi, Ramin Radfar, Mandana Sadeghi, Hamed Bahari, Mona Eslami, Alireza Noroozi, Omid Massah, Elaheh Ahounbar, Ali Farhoudian   +11 more
doaj   +2 more sources

Comparing Marital Adjustment in Couples Having Alcohol- or Opioid-dependent Husbands

Indian Journal of Psychological Medicine
Background: Substance use disorder is a complex bio-psycho-social phenomenon affecting the intimate relationship of substance users with their wives. Marital adjustment may be affected due to the ongoing substance use involving the family unit.
Sayani Bisoi, Gauri Shanker Kaloiya, Anju Dhawan, Siddharth Sarkar   +3 more
doaj   +1 more source

Effects of cue-synchronized parietal cathodal tDCS on internet gaming disorder: A randomized double-blind sham-controlled trial

Brain Stimulation
Background and objectives: Internet Gaming Disorder (IGD) is prevalent with limited treatment efficacy. Targeting reducing craving triggered by gaming cues is a critical therapeutic objective.
Yixuan Song, Yuchen Huang, Qihong Zheng, Xiaoqin Yang, Yang Guo, Yanan Geng, Huixing Gou, Junjie Bu, Tianye Jia, Guangdong Zhou, Lin Lu, Jie Shi, Yan Sun   +12 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Relapse Among Patients Referring to Residential Rehabilitation Centers for Drug Use Disorders in Iran and Its Related Factors

Iranian Rehabilitation Journal, 2018
Objectives: In this study, we aimed to determine the individual characteristics of clients who were referred to residential rehabilitation centers for drug use disorders and to determine their relapse-related factors.
Omid Massah, Farhad Taremian, Reza Moloodi, Mohammad Hassan Farhadi, Elaheh Ahounbar   +4 more
doaj